Unsaturated fatty acid-induced non-canonical autophagy: unusual? Or unappreciated?

The EMBO Journal
Vytas A Bankaitis

Abstract

The breakdown of cellular components via autophagy is crucial for cellular homeostasis.In this issue of The EMBO Journal,Niso-Santano et al (2015) report the important observation that feeding cells with saturated or unsaturated fatty acids triggers mechanistically distinct autophagic responses. Feeding cells saturated fatty acid induced the canonical, BECN1/PI3K dependent autophagy pathway. Conversely,the unsaturated fatty acid oleate triggered autophagic responses that were independent of the BECN1/PI3K complex, but that required a functional Golgi system.

References

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Sep 23, 2014·Cell Death and Differentiation·L GalluzziG Kroemer
Jan 15, 2015·The EMBO Journal·Mireia Niso-SantanoGuido Kroemer

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Citations

Oct 22, 2016·Biochimica Et Biophysica Acta·Purvi C TrivediThomas Pulinilkunnil
Jun 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yaping WangYuji Kamijo
Apr 2, 2021·The EMBO Journal·Maria Elena CicardiDavide Trotti

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