PMID: 3762564Sep 1, 1986Paper

Unscheduled DNA synthesis after beta-irradiation of mouse skin in situ

Mutation Research
A Ootsuyama, H Tanooka

Abstract

The skin of ICR mouse was irradiated with beta-rays from 90Sr-90Y with surface doses up to 30 krad. Unscheduled DNA synthesis (UDS) was measured by autoradiography after labeling the skin with radioactive thymidine using the forceps-clamping method. The level of UDS in epithelial cells of the skin was detected as an increasing function of radiation dose. Fibroblastic cells, compared with epithelial cells and hair follicle cells at the same depth of the skin, showed a lower level of UDS, indicating a lower DNA repair activity in fibroblasts. Cancer risk of the skin was discussed.

References

Feb 1, 1972·Mutation Research·R B Painter, B R Young
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P V Hariharan, P A Cerutti
Apr 1, 1966·The Journal of Cell Biology·R E Rasmussen, R B Painter
Oct 28, 1967·Nature·R B Painter, J E Cleaver
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G W TeeborM S Goldstein
Aug 1, 1964·Journal of Molecular Biology·D PETTIJOHN, P HANAWALT

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