Unsedated transnasal endoscopy with ultrathin endoscope as a screening tool for research studies.

The Laryngoscope
Robert M SiwiecR Shaker

Abstract

Asymptomatic subjects volunteering for research studies are generally stratified as healthy based on a questionnaire, medical interviewing, and physical examination. The aim of this study was to evaluate the prevalence of upper gastrointestinal (GI) abnormalities in healthy asymptomatic volunteers using unsedated transnasal esophagogastroduodenoscopy (T-EGD) with an ultrathin endoscope as an additional screening tool. A prospective study from one academic medical center with extensive experience in T-EGD. Consecutive 150 subjects volunteering for research studies were initially screened by using a gastroesophageal reflux disease (GERD) questionnaire, interviewing, and examination. Based on these, they were stratified as healthy asymptomatic volunteers or with GERD. Unsedated T-EGD was then performed by a faculty member who was blinded to the results of the initial assessment. On initial assessment using GERD questionnaire, medical interviewing, and physical examination, of the total 150 consecutive research volunteers, 83 (average age 33 ± 16 years; 46 females, 37 males) subjects were healthy asymptomatic volunteers and 67 (average age 36 ± 15 years; 35 females, 32 males) had symptoms of GERD. On T-EGD, GI pathology was found i...Continue Reading

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Citations

Nov 5, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R M SiwiecR Shaker
May 13, 2017·Head & Neck·David J WellensteinGuido B van den Broek
Jul 8, 2020·United European Gastroenterology Journal·Inês Marques de SáMário Dinis-Ribeiro
Nov 30, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Heiko FruehaufThomas Greuter

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