Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity

Circulation
K J MolloyI M Loftus

Abstract

The fibrous cap of atherosclerotic plaques is composed predominantly of type I and III collagen. Unstable carotid plaques are characterized by rupture of their cap, leading to thromboembolism and stroke. The proteolytic mechanisms causing plaque disruption are undefined, but the collagenolytic matrix metalloproteinase (MMP) -1, -8, and -13 may be implicated. The aim of this study was to quantify the concentrations of these collagenases in carotid plaques and to determine their relationship to markers of plaque instability. Atherosclerotic plaques were collected from 159 patients undergoing carotid endarterectomy. The presence and timing of carotid territory symptoms were ascertained. Preoperative embolization was recorded by transcranial Doppler. Each plaque was assessed for histological features of instability. Plaque MMP concentrations were quantified with ELISA. Significantly higher concentrations of active MMP-8 were observed in the plaques of symptomatic patients (20.5 versus 11.4 ng/g; P=0.0002), in plaques of emboli-positive patients (22.7 versus 13.5 ng/g; P=0.0037), and in those plaques showing histological evidence of rupture (20.8 versus 14.7 ng/g; P=0.0036). No differences were seen in the levels of MMP-1 and MMP-13...Continue Reading

References

Aug 1, 1991·Clinical Science·N Vine, J T Powell
Jan 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M E GauntA R Naylor
May 1, 1996·Journal of Vascular Surgery·S CarrJ S Yao
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D C Talbot, P D Brown
Jun 26, 1999·The British Journal of Surgery·I J FranklinJ T Powell
May 25, 2002·The British Journal of Surgery·Ian M LoftusM M Thompson
Jun 14, 2002·Cardiovascular Research·Mark D Rekhter
May 29, 2003·Circulation·Clare M DolleryPeter Libby

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Citations

Jul 20, 2010·Amino Acids·T Klein, R Bischoff
Jul 11, 2013·Molecular and Cellular Biochemistry·Yongjun CaoChunfeng Liu
Aug 24, 2005·Journal of Cardiovascular Pharmacology·Greta L HoetzerChristopher A DeSouza
Aug 31, 2012·Journal of Orthopaedic Trauma·Ru LiEmil H Schemitsch
Feb 28, 2009·Journal of Cardiovascular Pharmacology·Fu-Yu QiuGuo-Sheng Fu
Jan 6, 2012·Journal of Cardiovascular Pharmacology·Paulina FernandezClaudio Aguayo
Feb 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Tanja K RudolphBruce A Freeman
Apr 18, 2013·Medicine and Science in Sports and Exercise·Thibaut GuiraudAtul Pathak
Jul 10, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ting-Hin LukHung-Fat Tse
Apr 2, 2011·Future Cardiology·Alamgir M N KabirAlexander M Seifalian
Jul 1, 2008·Future Cardiology·Salman RahmanMichael S Sobel
Mar 7, 2014·Cardiology in Review·Robert E Michler
Nov 6, 2004·Current Rheumatology Reports·Laura E Schanberg, Christy Sandborg
Aug 15, 2006·Journal of Medical Genetics·Sonia AbilleiraHugh S Markus
Jun 16, 2005·Current Opinion in Cardiology·Edward D Frohlich
Dec 3, 2014·Pharmacology & Therapeutics·Shu Ye
Aug 14, 2009·Atherosclerosis·Yukihiko MomiyamaFumitaka Ohsuzu
Apr 5, 2016·International Journal of Nephrology·Andreas KousiosAndrie G Panayiotou
Feb 23, 2007·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·A Ross Naylor
Jan 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christina L AquilanteIssam Zineh
Jul 14, 2010·Journal of Clinical Laboratory Analysis·Tamara DjurićDragan Alavantić
May 23, 2006·Atherosclerosis·Anne LeclercqJean-Baptiste Michel
Feb 1, 2013·Mediators of Inflammation·Sébastien LengletFabrizio Montecucco
Dec 25, 2007·American Journal of Surgery·Michiel G van der VaartClark J Zeebregts
May 8, 2010·Journal of the American College of Cardiology·Shreenidhi M VenurajuAvijit Lahiri
Apr 10, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S SayedI M Loftus
Feb 1, 2007·Journal of Vascular Surgery·Willem E HellingsFrans L Moll
Jan 20, 2012·International Journal of Cardiology·Pirkko J PussinenErkki Pesonen

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