PMID: 590846Nov 1, 1977

Unstirred layer and kinetics of electrogenic glucose absorption in the human jejunum in situ

Gut
N W ReadC D Holdsworth

Abstract

Using an electrical technique we estimated the thickness of the unstirred layer in the human jejunum during kinetic studies of electrogenic glucose absorption. The unstirred layer in seven healthy volunteers (632 +/- 24 mum: mean +/- SEM) was significantly thicker than in 10 patients with active coeliac disease (442 +/- 23 mum) but not significantly different in seven patients who had responded to treatment by gluten withdrawal (585 +/- 49 mum). There were similar differences in the values of ;Apparent Km' for electrogenic glucose absorption between healthy control subjects (36 +/- 6 mM) active coeliac patients (11 +/- 1 mM) and treated coeliac patients (31 +/- 5 mM). The changes in PDmax however, showed a different pattern. The PDmax in the active coeliac group (6.8 +/- 0.7 mV) was lower than in controls (7.6 +/- 0.6 mV) but not significantly so, while the PDmax in the treated coeliac group (10.6 +/- 0.9 mV) was significantly higher than in both the active coeliac and control groups. It should be noted that both operational kinetic parameters obtained in the present study are much lower than those obtained previously (Read et al., 1976b) because of the use of siphonage. Analysis of the results using a computer simulation indic...Continue Reading

References

Feb 27, 1973·Biochimica Et Biophysica Acta·D Winne
Jun 1, 1974·The Biochemical Journal·R Eisenthal, A Cornish-Bowden
Aug 21, 1974·Biochimica Et Biophysica Acta·F A Wilson, J M Dietschy
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Feb 27, 1953·The Journal of Physiology·R B FISHER, D S PARSONS
May 1, 1957·The American Journal of Digestive Diseases·W H CROSBY, H W KUGLER

Citations

Sep 12, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·D Winne
Jul 1, 1980·European Journal of Clinical Pharmacology·G Heimann
Apr 1, 1982·Pflügers Archiv : European journal of physiology·I T Johnson, J M Gee
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·A B ThomsonW M Weinstein
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·R J LevinD C Barber
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·F MurilloJ Bolufer
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Bugaut
Mar 4, 1989·Lancet·P S BaxterC J Taylor
Dec 1, 1984·The Journal of Clinical Investigation·M D LevittD G Levitt
Aug 1, 1986·The Journal of Clinical Investigation·M S HarrisH J Binder
Nov 1, 1990·The Journal of Clinical Investigation·M D LevittD G Levitt
Oct 24, 1985·Biochimica Et Biophysica Acta·J BoluferM L Murillo
Jul 1, 1990·Scandinavian Journal of Gastroenterology·B H Sparsø, M Luke
Nov 1, 1994·Scandinavian Journal of Gastroenterology·S Oltmer, W von Engelhardt
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Related Concepts

Celiac Disease
Computers, Digital
Glucose, (beta-D)-Isomer
Intestinal Absorption
Jejunum
Potentiometry

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