DOI: 1812.00030Nov 30, 2018Paper

Unsupervised learning with GLRM feature selection reveals novel traumatic brain injury phenotypes

Aaron J Masino, Kaitlin A Folweiler


Baseline injury categorization is important to traumatic brain injury (TBI) research and treatment. Current categorization is dominated by symptom-based scores that insufficiently capture injury heterogeneity. In this work, we apply unsupervised clustering to identify novel TBI phenotypes. Our approach uses a generalized low-rank model (GLRM) model for feature selection in a procedure analogous to wrapper methods. The resulting clusters reveal four novel TBI phenotypes with distinct feature profiles and that correlate to 90-day functional and cognitive status.

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.