PMID: 2108584Apr 1, 1990Paper

Unsustained central sexual precocity in four girls

The American Journal of the Medical Sciences
H P SchwarzK Zuppinger

Abstract

Four girls who presented with breast enlargement at 4-5.8 years of age have been followed without specific therapy for up to 4 years. Three had normal CT brain scans, one had normal skull and sella x-rays. Stimulation of gonadotropins by LHRH was excessive in all but plasma estradiol levels were only intermittently elevated. Initially, bone age was advanced and height velocity was increased in three of the four. Ultrasound visualized an enlarged uterus in two and waxing and waning ovarian cysts in all. The clinical course was characterized by persistence of physical signs over at least 3.4 years in one patient, fluctuation in another, and marked regression in two. We propose that some patients with central precocious puberty may spontaneously have a nonprogressive course which has to be considered when evaluating the efficiency of drugs interfering with puberty.

References

Jul 1, 1987·The Journal of Clinical Endocrinology and Metabolism·H P SchwarzK A Zuppinger
Mar 1, 1988·American Journal of Diseases of Children·S J ClarkM S Edwards
Apr 9, 1987·The New England Journal of Medicine·H KodamaM Yanagisawa
Feb 1, 1985·Archives of Disease in Childhood·S SalardiA Reggiani
Sep 1, 1985·Archives of Disease in Childhood·A J LyonD B Grant
Nov 1, 1984·Acta paediatrica Scandinavica·A IlickiZ Laron
Jan 1, 1984·Archives of Disease in Childhood·D MurramD B Grant
May 1, 1983·Archives of Disease in Childhood·S A IvarssonP H Persson

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Citations

Mar 5, 2002·Clinical Endocrinology·Carl-Joachim PartschWolfgang G Sippell
Feb 13, 2016·Chonnam Medical Journal·Sang Heon LeeMi-Young Kim

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