Unsynchronized nasal intermittent positive pressure versus nasal continuous positive airway pressure in preterm infants after extubation

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Zelal KahramanerEsra Arun Ozer

Abstract

To determine the effect of unsynchronized nasal intermittent positive pressure ventilation compared to continuous positive airway pressure in preterm infants after extubation. A total of 67 premature infants who were <35 weeks gestation and/or <2000 g birth weight and received mechanical ventilation because of respiratory distress syndrome (RDS) were studied. Infants were randomized to receive either unsynchronized nasal intermittent positive pressure ventilation (NIPPV) with shortened endotracheal tube (Group 1) or nasal continuous positive airway pressure (NCPAP) with binasal prongs (Group 2) after extubation. Extubation failure and neonatal outcomes were recorded in each group. There were no significant differences in clinical characteristics between the two groups. The prevalence of re-intubation and post-extubation atelectasis were higher in CPAP group (p = 0.03 and p = 0.01). No differences were observed in the prevalence of IVH, ROP, PDA, NEC, sepsis, pneumothorax, BPD and BPD/death between the groups while the mortality was higher in NCPAP group (p < 0.01). Neither procedure had any serious side effects such as intestinal perforation. NIPPV (although non-synchronized and delivered by single nasal prong) had a better eff...Continue Reading

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Citations

Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bonny JasaniVineet Bhandari
Dec 25, 2015·Expert Review of Respiratory Medicine·Anne Greenough, Ingran Lingam
Nov 26, 2015·Clinics in Perinatology·Raouf S Amin, Michael J Rutter
Feb 29, 2016·Seminars in Fetal & Neonatal Medicine·Louise S Owen, Brett J Manley
Sep 8, 2012·Clinics in Perinatology·G M Sant'Anna, Martin Keszler
Jul 15, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·David MillarRobin S Roberts
Jun 13, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·H Al-MandariG Sant'Anna
May 28, 2020·Frontiers in Pediatrics·Ibrahim Sammour, Sreenivas Karnati

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