Untangling Cortical Complexity During Development

Journal of Experimental Neuroscience
Tanzila Mukhtar, Verdon Taylor

Abstract

The cerebral cortex is composed of billions of morphologically and functionally distinct neurons. These neurons are produced and organized in a regimental fashion during development. The ability of neurons to encode and elicit complex cognitive and motor functions depends on their precise molecular processes, identity, and connectivity established during development. Elucidating the cellular and molecular mechanisms that regulate development of the neocortex has been a challenge for many years. The cerebral cortical neuronal subtypes are classified based on morphology, function, intrinsic synaptic properties, location, connectivity, and marker gene expression. Development of the neocortex requires an orchestration of a series of processes including the appropriate determination, migration and positioning of the neurons, acquisition of layer-specific transcriptional hallmarks, and formation of precise axonal projections and networks. Historically, fate mapping, genome-wide analysis, and transcriptome profiling have provided many opportunities for the characterization of neuronal subtypes. During the course of this review, we will address the regimental organization of the cerebral cortex, dissect the cellular subtypes that contr...Continue Reading

References

Feb 20, 1998·Journal of Neuroscience Research·T EbendalS Söderström
May 28, 1998·Current Biology : CB·K L Blaschuk, C ffrench-Constant
Dec 23, 1999·Current Biology : CB·V EaswaranS Byers
Jan 3, 2001·Developmental Biology·Eva HartfussMagdalena Götz
Feb 13, 2001·Mechanisms of Development·M Bachler, A Neubüser
Sep 22, 2001·Science·T Fukuchi-Shimogori, E A Grove
Mar 16, 2002·Nature Neuroscience·N HeinsMagdalena Götz
Apr 2, 2002·Molecular and Cellular Neurosciences·N HeinsMagdalena Götz
Jun 8, 2002·Annual Review of Neuroscience·Nicholas Gaiano, Gord Fishell
Jul 16, 2002·Nature Neuroscience·Luca MuzioAntonello Mallamaci
Mar 12, 2003·Neuron·Paolo MalatestaMagdalena Götz
May 23, 2003·Glia·Arnold R Kriegstein, Magdalena Götz
Sep 11, 2003·Developmental Neuroscience·Robert F HevnerChris Englund
Jan 3, 2004·Nature Neuroscience·Stephen C NoctorArnold R Kriegstein
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wulf HaubensakWieland B Huttner
Sep 29, 2004·The Journal of Comparative Neurology·Marta NietoChristopher A Walsh
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroshi HasegawaYasuto Tanabe
Oct 12, 2004·Trends in Genetics : TIG·Nobuyuki Itoh, David M Ornitz
Jan 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris EnglundRobert F Hevner
Jun 7, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Flávia Carvalho Alcantara GomesLuciana Romão
Nov 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bin ChenSusan K McConnell
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan S GalTarik F Haydar
Jan 24, 2006·Nature Reviews. Neuroscience·Angeliki Louvi, Spyros Artavanis-Tsakonas
Mar 28, 2007·Nature Reviews. Genetics·Patrick P L Tam, David A F Loebel
May 22, 2007·Nature Reviews. Neuroscience·Bradley J MolyneauxJ D Macklis
Sep 1, 2007·The Journal of Endocrinology·Ulla-Maj Fiúza, Alfonso Martinez Arias
Apr 11, 2008·Neuron·Hiromi ShimojoRyoichiro Kageyama
May 30, 2008·Current Opinion in Neurobiology·Dino P LeoneSusan K McConnell
Aug 22, 2008·Nature·Nicolas GaspardPierre Vanderhaeghen
Feb 12, 2009·Journal of Cell Science·Rubén Alvarez-Rodríguez, Sebastián Pons
Apr 22, 2009·Development, Growth & Differentiation·Tomoko Iwata, Robert F Hevner
Jan 20, 2010·Nature Reviews. Genetics·Valentina PerissiMichael G Rosenfeld
Feb 16, 2010·Nature·David V HansenArnold R Kriegstein
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Itaru ImayoshiRyoichiro Kageyama
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth K StancikTarik F Haydar
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·João D PereiraFrederick J Livesey
Sep 14, 2010·Journal of Cellular Physiology·Lorraine J Gudas, John A Wagner
Sep 28, 2010·Neuron·Elena Taverna, Wieland B Huttner
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atsunori ShitamukaiFumio Matsuzaki
Apr 12, 2011·Nature Neuroscience·Xiaoqun WangArnold R Kriegstein
May 26, 2011·Neuron·David V HansenArnold R Kriegstein
Jul 7, 2011·Cell·Jan H LuiArnold R Kriegstein
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Maria K Lehtinen, Christopher A Walsh
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian G RashFlora M Vaccarino
Apr 21, 2012·Developmental Cell·Darren J YipDavid J Picketts
May 5, 2012·Current Opinion in Neurobiology·Madeline A Lancaster, Juergen A Knoblich
Aug 11, 2012·Science·Santos J FrancoUlrich Müller
Nov 8, 2012·CNS & Neurological Disorders Drug Targets·Griselda Rodríguez-Martínez, Iván Velasco
Nov 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karpagam SrinivasanSusan K McConnell
May 7, 2013·Developmental Cell·Tran Cong TuocAnastassia Stoykova
Jul 3, 2013·Nature Neuroscience·Holden HigginbothamE S Anton
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Xin Tan, Song-Hai Shi
Oct 10, 2013·Nature Reviews. Neuroscience·L C GreigJ D Macklis
Dec 10, 2013·Neuron·Wenqi Han, Nenad Sestan
Mar 19, 2014·EMBO Reports·Judith T M L Paridaen, Wieland B Huttner
Jul 9, 2014·Annual Review of Cell and Developmental Biology·Elena TavernaWieland B Huttner
Sep 23, 2014·Cell and Tissue Research·Nibaldo C Inestrosa, Lorena Varela-Nallar
Sep 23, 2014·Molecules and Cells·Hyun-Kyung LeeSally A Moody
Nov 12, 2014·Frontiers in Neuroscience·Pia A Johansson
Dec 7, 2014·Development·Katrin GerstmannGeraldine Zimmer
Mar 31, 2015·World Journal of Stem Cells·Jen-Hua ChuangYenshou Lin
Jul 18, 2015·Neurobiology of Disease·Xiangning Jiang, Jeannette Nardelli
Apr 7, 2017·Nature Reviews. Neuroscience·Brie Wamsley, Gord Fishell
Jun 18, 2017·Cell and Tissue Research·Runrui ZhangVerdon Taylor
Aug 10, 2017·Developmental Biology·Carole HaushalterMuriel Rhinn
Sep 8, 2017·Nature Reviews. Neuroscience·Elizabeth Di Lullo, Arnold R Kriegstein
Sep 28, 2017·Nature Reviews. Molecular Cell Biology·Tito PancieraStefano Piccolo
Oct 2, 2017·Trends in Biochemical Sciences·Kimberly C LinKun-Liang Guan
Nov 2, 2017·Development·Jia Sheng HuJohn L Rubenstein

Citations

Mar 15, 2020·Scientific Reports·Tanzila MukhtarVerdon Taylor
Jun 24, 2020·Journal of Medical Genetics·Stefanie BrockKatrien Stouffs
Aug 11, 2020·Seminars in Cell & Developmental Biology·Danyon HarkinsMichael Piper

Related Concepts

Axon
Biological Markers
Cerebral Cortex
Gene Expression
Neurons
Organ Culture Techniques
Synapses
Transcription, Genetic
Neocortex
Motor Function

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.