Sep 13, 2014

Untangling cross-frequency coupling in neuroscience

Current Opinion in Neurobiology
Juhan AruRaul Vicente

Abstract

Cross-frequency coupling (CFC) has been proposed to coordinate neural dynamics across spatial and temporal scales. Despite its potential relevance for understanding healthy and pathological brain function, the standard CFC analysis and physiological interpretation come with fundamental problems. For example, apparent CFC can appear because of spectral correlations due to common non-stationarities that may arise in the total absence of interactions between neural frequency components. To provide a road map towards an improved mechanistic understanding of CFC, we organize the available and potential novel statistical/modeling approaches according to their biophysical interpretability. While we do not provide solutions for all the problems described, we provide a list of practical recommendations to avoid common errors and to enhance the interpretability of CFC analysis.

  • References29
  • Citations73

References

  • References29
  • Citations73

Citations

Mentioned in this Paper

Fluctuation
Acropectoral Syndrome
Neurons
Brain
Fetishism (Psychiatric)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Etiology
Malformations of Cortical Development
Biophysics
Isolate compound

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