Untangling cross-frequency coupling in neuroscience

BioRxiv : the Preprint Server for Biology
Juhan AruRaul Vicente

Abstract

Cross-frequency coupling (CFC) has been proposed to coordinate neural dynamics across spatial and temporal scales. Despite its potential relevance for understanding healthy and pathological brain function, the standard CFC analysis and physiological interpretation come with fundamental problems. For example, apparent CFC can appear because of spectral correlations due to common non-stationarities that may arise in the total absence of interactions between neural frequency components. To provide a road map towards an improved mechanistic understanding of CFC, we organize the available and potential novel statistical/modeling approaches according to their biophysical interpretability. While we do not provide solutions for all the problems described, we provide a list of practical recommendations to avoid common errors and to enhance the interpretability of CFC analysis.

Related Concepts

Brain Pathology
Cross Reactions
Spatial Distribution
G-Protein-Coupled Receptors
Analysis
Neural Stem Cells
Statistical Technique

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Current Opinion in Neurobiology
Juhan AruRaul Vicente
Trends in Neurosciences
David M Eagleman, Terrence J Sejnowski
Nature
Scott Bolkan, Joshua A Gordon
© 2021 Meta ULC. All rights reserved