Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

Frontiers in Molecular Neuroscience
Shalini S Rao, Paul A Adlard

Abstract

There is an emerging link between the accumulation of iron in the brain and abnormal tau pathology in a number of neurodegenerative disorders, such as Alzheimer's disease (AD). Studies have demonstrated that iron can regulate tau phosphorylation by inducing the activity of multiple kinases that promote tau hyperphosphorylation and potentially also by impacting protein phosphatase 2A activity. Iron is also reported to induce the aggregation of hyperphosphorylated tau, possibly through a direct interaction via a putative iron binding motif in the tau protein, facilitating the formation of neurofibrillary tangles (NFTs). Furthermore, in human studies high levels of iron have been reported to co-localize with tau in NFT-bearing neurons. These data, together with our own work showing that tau has a role in mediating cellular iron efflux, provide evidence supporting a critical tau:iron interaction that may impact both the symptomatic presentation and the progression of disease. Importantly, this may also have relevance for therapeutic directions, and indeed, the use of iron chelators such as deferiprone and deferoxamine have been reported to alleviate the phenotypes, reduce phosphorylated tau levels and stabilize iron regulation in v...Continue Reading

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Nov 3, 1992·Biochemistry·A AndreadisK S Kosik
Jan 1, 1992·Electron Microscopy Reviews·T C Iancu
Jun 1, 1991·Lancet·D R Crapper McLachlanD F Andrews
Jan 1, 1990·Acta Neuropathologica·I Grundke-IqbalJ G Joshi
Oct 1, 1985·The Journal of Cell Biology·L I BinderL I Rebhun
Jul 1, 1984·Annals of Neurology·K F Swaiman, V L Machen
Jun 24, 1982·The New England Journal of Medicine·C A Finch, H Huebers
Nov 1, 1982·Journal of the Neurological Sciences·G K Wilcock, M M Esiri
Jun 16, 1995·Neuroscience Letters·D Y HuangW J Strittmatter
Jan 1, 1995·Journal of Neurochemistry·S BodovitzW L Klein
Mar 3, 1995·The Journal of Biological Chemistry·J Z WangK Iqbal
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Aug 16, 1994·Biochemistry·N GustkeE Mandelkow
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M GoedertV M Lee
Jan 1, 1997·Molecular and Cellular Neurosciences·A FerreiraK S Kosik
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Oct 6, 1997·The Journal of Biological Chemistry·M HongV M Lee
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaB Wolozin
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·L N ClarkK C Wilhelmsen
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·N C Andrews

❮ Previous
Next ❯

Citations

May 6, 2020·Radiology·Boris-Stephan RauchmannUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 4, 2020·Experimental Biology and Medicine·Santosh R D'Mello, Mark C Kindy
Jul 13, 2019·Frontiers in Aging Neuroscience·Carolina OsorioAdonis Sfera
Aug 11, 2020·Movement Disorders Clinical Practice·Eoin MulroyKailash P Bhatia
Mar 27, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sonja M KagererPaul G Unschuld
May 16, 2020·Oxidative Medicine and Cellular Longevity·Alyne Mendonça Marques TonElisardo Corral Vasquez
Feb 18, 2020·Frontiers in Neuroscience·Nao Yan, JunJian Zhang
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Shalini S RaoPaul A Adlard
Apr 15, 2020·Neuroradiology·Sirio CocozzaArturo Brunetti
Oct 29, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew Gleason, Ashley I Bush
Sep 24, 2021·Journal of Neurochemistry·Md JakariaScott Ayton

❮ Previous
Next ❯

Methods Mentioned

BETA
circular
nuclear
X-ray
ubiquitination
transgenic
NMR

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

Current Alzheimer Research
A BoutajangoutP K Krishnamurthy
Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Rong-Hong MaGong-Ping Liu
Progress in Molecular Biology and Translational Science
Steven P BraithwaiteAngus C Nairn
© 2022 Meta ULC. All rights reserved