Untangling the most probable role for vitamin D3 in autism

Dermato-endocrinology
Dianne E Godar, Stephen J Merrill

Abstract

Recent studies indicate an important role for vitamin D3 in autism spectrum disorder (ASD), although its mechanism is not completely understood. The most puzzling aspect of ASD is that identical twins, who share identical DNA, do not have 100% concordance rates (∼88% for identical and ∼31% for fraternal twins). These findings provide major clues into the etiology: ASD must involve an environmental factor present in the prenatal milieu that both identical twins are not always exposed to because they do not always share it (i.e., placentas). Combined with the exponential increasing rates of ASD around the world, these observations suggest a contagious disease is probably transferred to the fetus via the placenta becoming infected by a cervical virus. Vitamin D3 boosts immune responses clearing viral infections and increases serotonin and estrogen brain levels. Here we review the different roles and untangle the most probable one vitamin D3 plays in ASD.

References

Nov 10, 1998·Biological Psychiatry·D R RubinowC A Roca
Apr 30, 1999·American Journal of Epidemiology·K DemissieG G Rhoads
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S E TaymansC A Stratakis
Dec 2, 2000·Paediatric and Perinatal Epidemiology·S W WenM S Kramer
Apr 16, 2002·American Journal of Human Genetics·Catalina BetancurChristopher Gillberg
May 4, 2002·Journal of Women's Health & Gender-based Medicine·Ilana G DzubaJorge Salmerón
Sep 28, 2002·Current Opinion in Pediatrics·Karoly Horvath, Jay A Perman
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Marshalyn Yeargin-AllsoppCatherine Murphy
Nov 1, 2003·American Journal of Physiology. Cell Physiology·J PraetoriusS Nielsen
Nov 17, 2004·Annals of Neurology·Diana L VargasCarlos A Pardo
Apr 4, 2006·Obstetrics and Gynecology·Darios GetahunCande V Ananth
Jul 13, 2006·Environmental Health Perspectives·Irva Hertz-PicciottoIsaac N Pessah
Sep 5, 2006·Journal of Autism and Developmental Disorders·Tanya Karapurkar Bhasin, Diana Schendel
Oct 7, 2006·Virology·Nicole BrimerScott B Vande Pol
Jan 30, 2007·The Journal of Steroid Biochemistry and Molecular Biology·David BarreraLorenza Díaz
Mar 10, 2007·Journal of Autism and Developmental Disorders·Paul AshwoodJudy Van de Water
Mar 17, 2007·Science·Jonathan SebatMichael Wigler
Apr 26, 2007·The Journal of Clinical Endocrinology and Metabolism·Sabine RohrmannElizabeth A Platz
Jul 11, 2007·Archives of Neurology·Nancy J Minshew, Diane L Williams
Oct 9, 2007·Medical Hypotheses·John Jacob Cannell
Jan 16, 2008·Physiological Reviews·Margaret M McCarthy
Sep 27, 2008·Virology Journal·Renato L RombaldiKamille P Losquiavo
Mar 25, 2009·Archives of Internal Medicine·Adit A GindeCarlos A Camargo
Oct 7, 2009·Archives of Pediatrics & Adolescent Medicine·Rebecca E RosenbergPaul A Law
Dec 25, 2009·Acta Neuropathologica·Hartwig Wolburg, Werner Paulus
Mar 9, 2010·Nature Immunology·Marina Rode von EssenCarsten Geisler
Mar 20, 2010·Infectious Diseases in Obstetrics and Gynecology·Elaine M SmithLubomir P Turek
Apr 24, 2010·Journal of Autism and Developmental Disorders·Hjördis O AtladóttirErik T Parner
Jan 7, 2011·The Journal of Infectious Diseases·Christine WeynVéronique Fontaine
Jan 19, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jeremy A BeardRob Striker
Mar 2, 2011·Current Genomics·Cassandra L SmithGiang Nguyen

❮ Previous
Next ❯

Citations

Apr 25, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Liyao SongAi Chen
Apr 18, 2019·Journal of Autism and Developmental Disorders·Loai AlzghoulOsama Abu Hantash

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
chip

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

© 2022 Meta ULC. All rights reserved