Untangling the relationship between medication adherence and post-myocardial infarction outcomes: medication adherence and clinical outcomes

American Heart Journal
Niteesh K ChoudhryWilliam H Shrank

Abstract

Patients who adhere to medications experience better outcomes than their nonadherent counterparts. However, these observations may be confounded by patient behaviors. The level of adherence necessary for patients to derive benefit and whether adherence to all agents is important for diseases that require multiple drugs remain unclear. This study quantifies the relationship between medication adherence and post-myocardial infarction (MI) adverse coronary events. This is a secondary analysis of the randomized MI FREEE trial. Patients who received full prescription coverage were classified as adherent (proportion of days covered ≥80%) or not based upon achieved adherence in the 6 months after randomization. First major vascular event or revascularization rates were compared using multivariable Cox models adjusting for comorbidity and health-seeking behavior. Compared with patients randomized to usual care, full coverage patients adherent to statin, β-blocker, or angiotensin-converting enzyme inhibitor/angiotensin receptor blocker were significantly less likely to experience the study's primary outcome (hazard ratio [HR] range 0.64-0.81). In contrast, nonadherent patients derived no benefit (HR range 0.98-1.04, P ≤ .01 for the diff...Continue Reading

References

Jul 21, 1975·JAMA : the Journal of the American Medical Association·S W FletcherM A Bourgeois
Jul 1, 1992·Computer Methods and Programs in Biomedicine·D Y Lin
Jan 1, 1997·Journal of Clinical Epidemiology·J F Steiner, A V Prochazka
Mar 27, 2001·Journal of the American College of Cardiology·J V TuK M McDonald
May 25, 2005·Archives of Internal Medicine·Richard H ChapmanJ Sanford Schwartz
Jun 1, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jacob A UdellNiteesh K Choudhry
Sep 27, 2006·Archives of Internal Medicine·P Michael HoJohn S Rumsfeld
Jan 11, 2007·JAMA : the Journal of the American Medical Association·Jeppe N RasmussenDavid A Alter
Mar 29, 2007·Archives of Internal Medicine·Sunil KripalaniR Brian Haynes
Oct 29, 2008·Pharmacoepidemiology and Drug Safety·Niteesh K ChoudhryWilliam H Shrank
Apr 8, 2009·Circulation·Colin R DormuthM Alan Brookhart
Nov 6, 2009·Medical Care·David C ChanNiteesh K Choudhry
Jan 7, 2011·Health Affairs·M Christopher RoebuckTroyen A Brennan
May 11, 2011·Archives of Internal Medicine·Niteesh K ChoudhryWilliam H Shrank
Nov 15, 2011·The New England Journal of Medicine·Niteesh K ChoudhryUNKNOWN Post-Myocardial Infarction Free Rx Event and Economic Evaluation (MI FREEE) Trial

❮ Previous
Next ❯

Citations

Sep 2, 2015·Scandinavian Journal of Rheumatology·L Kuusalo For The Neo-RACo Study Group
Apr 24, 2015·Pharmacoepidemiology and Drug Safety·Jessica M FranklinNiteesh K Choudhry
Apr 22, 2016·International Journal of Cardiology·Maarit Jaana KorhonenJussi Vahtera
Aug 20, 2016·Journal of the American College of Cardiology·Sameer BansilalValentin Fuster
Aug 5, 2016·Cardiovascular Therapeutics·Anthony S GunnellFrank M Sanfilippo
Jul 23, 2015·European Journal of Preventive Cardiology·Hatem HamoodRonit Almog
Jan 5, 2017·Journal of General Internal Medicine·Julie C LauffenburgerMichael A Fischer
Mar 3, 2017·Heart·Beatriz González López-ValcárcelGabriel Sanfélix-Gimeno
Jan 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard Ofori-AsensoSophia Zoungas
Oct 21, 2016·Journal of General Internal Medicine·John F Steiner
Oct 11, 2017·Pharmacoepidemiology and Drug Safety·Walid F GelladCorrine I Voils
Aug 10, 2016·Health Affairs·Jalpa A DoshiKevin G Volpp
Apr 17, 2018·Journal of Diabetes·Richard Ofori-AsensoDanny Liew
Oct 21, 2015·Circulation·Eric C SteckerA Mark Fendrick
Jan 9, 2015·Journal of the American Heart Association·Stefano Di BartolomeoRossana De Palma
Nov 8, 2018·British Journal of Clinical Pharmacology·Richard Ofori-AsensoDanny Liew
Sep 22, 2017·Nature Reviews. Cardiology·Karam Turk-AdawiSherry L Grace
Jul 18, 2019·Pharmacoepidemiology and Drug Safety·Karandeep SinghJessica M Franklin
Jun 30, 2019·Journal of Diabetes·Zachary Bloomgarden
Nov 21, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Adhir R ShroffSamir B Pancholy
Jan 25, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael S WolfRuth M Parker
Dec 5, 2019·Pharmacoepidemiology and Drug Safety·Adjo Enyonam AkatorLine Guénette
Aug 20, 2014·International Journal of Clinical Pharmacy·Gina GujralW Neil Cottrell
Jan 29, 2016·Trials·Stephanie MathiesonChung-Wei Christine Lin
Apr 2, 2015·Journal of Cardiovascular Pharmacology and Therapeutics·Alexander TurinNeil J Stone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American College of Cardiology
Won Woo LeeMatthias Nahrendorf
Journal of Psychosomatic Research
Lynn WilliamsRonan E O'Carroll
Heart Rhythm : the Official Journal of the Heart Rhythm Society
Lakshminarayan YerraScott D Solomon
© 2021 Meta ULC. All rights reserved