Untargeted metabolomics: an overview of its usefulness and future potential in prenatal diagnosis

Expert Review of Proteomics
Ewa ParfieniukCoral Barbas

Abstract

Metabolomics opens up new avenues for biomarker discovery in different branches of medicine, including perinatology. Chromosomal aberration, preterm delivery (PTD), congenital heart defects, spina bifida, chorioamnionitis, and low birth weight are the main perinatal pathologies. Investigations using untargeted metabolomics have found the candidate metabolites for diagnostic biomarkers. Areas covered: This review describes areas of prenatal diagnosis in which untargeted metabolomics has been used. Data on the disease, type of sample, techniques used, number of samples used in the study, and metabolites obtained including the sign of their regulation are summarized. Expert commentary: Untargeted metabolomics is a powerful tool which can shed a new light on prenatal diagnostics. It helps to discover affected metabolic pathways what may help to reveal disease pathogenesis and propose potential biomarkers. Among others, glycerol and 2- and 3-hydroxybutyrate were proposed as markers of chromosomal aberration. Serum metabolic signature of PTD was characterized by increased lipids and decreased levels of hypoxanthine, tryptophane, and pyroglutamic acid. Lower level lipids and vitamin D3 metabolites together with increased bilirubin lev...Continue Reading

References

Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pascal M W GroenenRégine P M Steegers-Theunissen
Jul 29, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S H PoggiM Ossandon
May 28, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroChris Beecher
Sep 10, 2011·Journal of Proteome Research·Xiaoying ZhengWei Jia
Jan 15, 2013·American Journal of Obstetrics and Gynecology·Ray O Bahado-SinghKypros Nicolaides
Mar 29, 2013·American Journal of Obstetrics and Gynecology·Ray O Bahado-SinghKypros Nicolaides
Jan 21, 2014·Reproductive Sciences·Ramkumar MenonSanmaan Basraon
Apr 8, 2014·American Journal of Obstetrics and Gynecology·Ray O Bahado-SinghKypros H Nicolaides
Apr 16, 2014·Prenatal Diagnosis·Michal CiborowskiAdam Kretowski
Jul 30, 2015·American Journal of Obstetrics and Gynecology·Joana PintoAna Maria Gil
Sep 19, 2015·Taiwanese Journal of Obstetrics & Gynecology·Wei-Lun ChengTai-Ping Lee
Jun 21, 2016·International Journal of Cardiology·M Marcinkiewicz-SiemionK A Kaminski
Jan 10, 2017·Journal of Proteome Research·Christina VirgiliouGeorgios A Theodoridis
Jul 14, 2017·Archives of Gynecology and Obstetrics·Karl Oliver KaganMarkus Hoopmann
Oct 27, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xun MaoKai P Law
Feb 20, 2018·Indian Heart Journal·Nathalie Jeanne Bravo-ValenzuelaEdward Araujo Júnior
Apr 11, 2018·Expert Review of Molecular Diagnostics·Nicholas J Wald
Jul 1, 2017·Metabolomics : Official Journal of the Metabolomic Society·Rachel S KellyJessica Lasky-Su

❮ Previous
Next ❯

Citations

Jan 16, 2020·Metabolites·Álvaro Fernández-OchoaAntonio Segura-Carretero
Oct 9, 2020·Critical Reviews in Microbiology·Chaminda J SeneviratneGordon Ramage
Feb 8, 2021·Metabolomics : Official Journal of the Metabolomic Society·Nipun SainiSusan M Smith
Aug 17, 2021·Frontiers in Molecular Biosciences·Szymon MacioszekMichał J Markuszewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.