The Zika virus infection outbreak in Brazil in 2014 to 2015 resulted in the identification of previously unknown consequences of the disease, including the notorious microcephaly among many defects in fetuses born to women infected during pregnancy. A number of individuals were involved in this remarkable discovery, from the detection of viral circulation in the country to the studies on the causal link with congenital abnormalities and the provision of awareness and social support to families affected by the disease. In this article, we review the background to this experience, describing aspects of the epidemiology, medical research, and scientific response to the Zika virus outbreak in Brazil.
Evolutionary and ecological factors underlying the tempo and distribution of yellow fever virus activity
Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013
Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014
Differential replication of dengue virus serotypes 2 and 3 in coinfections of C6/36 cells and Aedes aegypti mosquitoes
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Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study
Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission - Continental United States, 2016
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
Causal or not: applying the Bradford Hill aspects of evidence to the association between Zika virus and microcephaly
Congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 Zika virus epidemic in French Polynesia
Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects
Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil
First International Workshop on Zika Virus Held by Oswaldo Cruz Foundation FIOCRUZ in Northeast Brazil March 2016 - A Meeting Report
Sexual transmission of Zika virus in an entirely asymptomatic couple returning from a Zika epidemic area, France, April 2016
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study
Local Mosquito-Borne Transmission of Zika Virus - Miami-Dade and Broward Counties, Florida, June-August 2016
Description of 13 Infants Born During October 2015-January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth - Brazil
Infant outcomes among women with Zika virus infection during pregnancy: results of a large prenatal Zika screening program
Guillain-Barré syndrome and other neurological manifestations possibly related to Zika virus infection in municipalities from Bahia, Brazil, 2015
Vital Signs: Update on Zika Virus-Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure - U.S. Zika Pregnancy Registry, 2016
Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections
Competence of Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus Mosquitoes as Zika Virus Vectors, China
Transmission Incompetence of Culex quinquefasciatus and Culex pipiens pipiens from North America for Zika Virus
Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes
Mosquito co-infection with Zika and chikungunya virus allows simultaneous transmission without affecting vector competence of Aedes aegypti
Pregnancy Outcomes After Maternal Zika Virus Infection During Pregnancy - U.S. Territories, January 1, 2016-April 25, 2017
Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study
Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae
Reduction of the birth rate in São Paulo: a probable effect of the panic caused by the Zika-associated microcephaly epidemic
Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice
Zika Virus Replication Is Substantially Inhibited by Novel Favipiravir and Interferon Alpha Combination Regimens
Zika virus disease, microcephaly and Guillain-Barré syndrome in Colombia: epidemiological situation during 21 months of the Zika virus outbreak, 2015-2017
High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks
Guillain-Barré Syndrome, Acute Disseminated Encephalomyelitis and Encephalitis Associated with Zika Virus Infection in Brazil: Detection of Viral RNA and Isolation of Virus during Late Infection
Outbreak of Guillain-Barré syndrome possibly related to prior Zika virus infection, Metropolitan Region of Recife, Pernambuco, Brazil, 2015
Improvement of data quality on the underlying cause of death from external causes using Health, Public Security and Press sector database linkage in the State of Rio de Janeiro, Brazil, 2014
Risk factors for death among patients with Chikungunya virus infection during the outbreak in northeast Brazil, 2016-2017
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