Unusual and Fatal Case of an Undiagnosed Intravascular Large B-cell Lymphoma: The Oncologist's Great Imitator†

Journal of Forensic Sciences
Rosario BarrancoFrancesco Ventura

Abstract

Intravascular lymphoma (IVL) is a rare subtype of extranodal lymphomas that is characterized by the selective growth of neoplastic cells within the lumen of small vessels. Authors document the case of an unexpected death caused by an undiagnosed intravascular large B-cell lymphoma with multi-organ involvement, which had initially manifested as an infection and then as an unclarified central nervous system pathology. Histological examination showed a diffuse intravascular large B-cell brain lymphoma with prominent cerebral involvement. The relevance of the case report reveals the importance of an autopsy of an extremely rare and threatening pathology that in most cases is diagnosed only postmortem. As a result, the role of the forensic pathologist becomes particularly important. When specifically performing an in-depth autopsy evaluation with a specific histologic analysis, it is possible to identify the intravascular lymphoma and declare a more accurate cause of death.

References

Mar 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·C Perniciaro
Jun 27, 1998·Leukemia & Lymphoma·V Bogomolski-YahalomA Polliack
Jun 1, 1999·Clinical Neurology and Neurosurgery·M VierenW Robberecht
Oct 6, 2004·British Journal of Haematology·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
May 25, 2006·The Oncologist·Dan ZuckermanEphraim Hochberg
May 25, 2006·Hematological Oncology·Maurilio Ponzoni, Andrés J M Ferreri
May 10, 2007·Haematologica·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurilio PonzoniShigeo Nakamura
Sep 1, 2009·The Lancet Oncology·Kazuyuki ShimadaShigeo Nakamura
Mar 23, 2011·Clinical and Experimental Dermatology·S WahieJ A A Langtry
Apr 12, 2016·Case Reports in Oncology·Daisuke UsudaShinichi Hayashi
Apr 21, 2016·European Journal of Haematology·Mohammad Faizan ZahidStefan K Barta
Aug 24, 2017·Current Treatment Options in Neurology·Damir NizamutdinovEkokobe Fonkem
Oct 14, 2018·Medicine·Muharrem YunceStephen Selinger

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Citations

Jun 3, 2020·The Journal of International Medical Research·Aniello MaieseVittorio Fineschi
Sep 21, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Andrea PorzionatoRaffaele De Caro

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