Unusual antigen presentation offers new insight into HIV vaccine design

Current Opinion in Immunology
Andrew J McMichael, Louis J Picker

Abstract

Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.

Citations

Sep 30, 2017·Viruses·Koollawat ChupraditChatchai Tayapiwatana
Mar 30, 2019·Current Opinion in HIV and AIDS·Santiago Avila-RiosZabrina L Brumme
Apr 11, 2019·Clinical and Experimental Immunology·H R SharpeT Lambe
Oct 20, 2019·Vaccines·Mario Alberto Ynga-DurandLuka Cicin-Sain
Sep 8, 2017·Expert Review of Vaccines·Mathieu SurenaudJean-Daniel Lelièvre

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