Unusual antimicrobial compounds from Aeollanthus buchnerianus

Experientia
J E DellarP G Waterman

Abstract

Using bioassay guided isolation, three novel 12 carbon polyoxygenated fatty acids and a novel abietane diterpene have been isolated from the chloroform extract of aerial parts of Aeollanthus buchnerianus (Lamiaceae). Rigorous spectroscopic methods were used for compound identification. (Z,Z)-8zeta-acetoxy-5zeta-hydroxydodeca-2,6-dienoic acid and (Z,Z)-5zeta, 8zeta-dihydroxydodeca-2,6-dienoic acid inhibited the spore germination of Cladosporium cucumerinum (both with Minimum Inhibitory Dose (MID) values of 1 microgram) and Aspergillus niger (MID 5 and 25 microgram respectively). Further, they also reduced the hyphal growth of Pythium ultimum. (Z)-5zeta-hydroxy-6zeta,7zeta,8zeta-triacetox ydodeca-2-dienoic acid exhibited short term inhibition of the growth of Cladosporium cucumerinum. The novel abietane diterpenoid, (rel)-14alpha-acetoxyabiet-7-en-18-oic acid inhibited the growth of the gram positive bacteria Bacillus subtilis, Staphylococcus aureus and Streptomyces scabies (MIC values 80, 20 and 20 micrograms ml(-1) respectively).

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Citations

May 1, 1996·Journal of Chemical Ecology·J E DellarP G Waterman
Nov 28, 2002·Phytochemistry·Hisayoshi KofujitaYoshiki Hayashi
Apr 6, 2012·Natural Product Research·Zohreh HabibiSabrieh Ghasemi
Jul 28, 2009·Phytochemistry·Patricia RijoBenjamín Rodríguez
Jun 5, 2020·Journal of Biomedical Materials Research. Part a·Magda S HanafyOsiris W Guirguis
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ryan D Rattray, Ben-Erik Van Wyk

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