PMID: 9546219Apr 18, 1998Paper

Unusual beta-sheet periodicity in small cyclic peptides

Nature Structural Biology
Alan C GibbsDavid S Wishart

Abstract

Cyclic peptide homologs of gramicidin S containing 6, 8, 10, 12, 14 and 16 residues were synthesized and characterized using circular dichroism (CD) and 1H NMR spectroscopy. Based on the three-dimensional structures generated from these data we have found strong evidence of a periodic sequence-length dependence on beta-sheet content. In particular, peptides of length 6, 10 and 14 residues exhibit a high beta-sheet content, while peptides of 8, 12 and 16 residues appear to exist as random coils. This unusual beta-sheet periodicity may have important implications in our understanding of beta-sheet formation and in the design of constrained beta-sheet and beta-hairpin mimics.

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Citations

Jun 6, 2003·Bioorganic & Medicinal Chemistry·Gijsbert M GrotenbregMark Overhand
Feb 14, 2007·Journal of the American Chemical Society·R Jeremy WoodsJames S Nowick
Mar 13, 2009·Journal of Medicinal Chemistry·Masoud Jelokhani-NiarakiRobert S Hodges
Apr 2, 2011·The Journal of Organic Chemistry·Pin-Nan Cheng, James S Nowick
Jul 17, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·K YamadaM Kawai
Jun 7, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Betsy L LytleBrian F Volkman
Feb 23, 2013·The Journal of Biological Chemistry·Anne C ConibearDavid J Craik
Apr 1, 2012·Drug Discovery Today. Technologies
May 18, 2011·Biophysical Journal·Anna D CiracDurba Sengupta
Oct 8, 2013·Biophysical Journal·Stephanie M CopeSara M Vaiana
May 20, 2016·Organic Letters·Attila VányolósZoltán Béni
Oct 4, 2016·Amino Acids·Alysha G ElliottK Johan Rosengren
Apr 25, 2017·ACS Chemical Biology·Matthew D ShortridgeGabriele Varani
Jun 30, 2016·Biopolymers·Bastian FrankeK Johan Rosengren
Feb 14, 2017·Organic & Biomolecular Chemistry·Andreas SchrimpfArmin Geyer
Jun 15, 2017·Journal of Chemical Information and Modeling·Yunhui GeVincent A Voelz
Jul 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maurício MoraisM Angeles Jiménez
Oct 19, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·M Jelokhani-NiarakiR S Hodges
Oct 17, 2018·Chembiochem : a European Journal of Chemical Biology·Yuan Qi YeohAndrew D Abell
Sep 6, 2007·Journal of Computational Chemistry·Xiaoqing LiuXiaohui Li
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Oct 20, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·L ChaloinF Heitz
Dec 12, 2018·Chembiochem : a European Journal of Chemical Biology·Yi-Ting SunGabriele Varani
Jul 3, 2003·The Journal of Biological Chemistry·Lior ZilberbergAndreas Bikfalvi
Jun 7, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Maud LarregolaSolange Lavielle
Jun 26, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·M Jelokhani-NiarakiR S Hodges
Mar 27, 1999·European Journal of Biochemistry·H WeisshoffC Mügge

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