PMID: 2114014Jun 25, 1990Paper

Unusual c-fos induction upon chromaffin PC12 differentiation by sodium butyrate: loss of fos autoregulatory function

Nucleic Acids Research
J R NaranjoP Sassone-Corsi

Abstract

Induction of PC12 pheochromocytoma cells neuronal differentiation upon treatment with nerve growth factor (NGF) is accompanied by a coupled stimulation of c-fos and c-jun oncogene transcription. We found that induction of c-fos and c-jun proto-oncogene mRNAs levels following the endocrine differentiation of PC12 cells by sodium butyrate is uncoupled. While c-fos mRNA level increased within minutes, the content of c-jun mRNA was significantly elevated only 24 hours after treatment. Continuous presence of sodium butyrate for 72 hours resulted in stable high levels of c-fos and c-jun mRNAs. Gene transcription of the other members of the jun family, jun B and jun D, was not significantly modified at any induction time. The early accumulation of c-fos mRNA was accompanied by increased levels of c-Fos protein. While the NGF-induced c-Fos protein migrates with an apparent homogeneous molecular weight of 62 kDa, the sodium butyrate-stimulated Fos protein is of heterogeneous lower molecular weight. The different gel mobility of the Fos immunoreactive bands induced by sodium butyrate and the sustained Fos mRNA levels after induction suggested that the sodium butyrate-induced c-Fos protein could be non-functional in the autoregulation of ...Continue Reading

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Citations

Mar 18, 1991·Brain Research. Developmental Brain Research·C González-MartínJ R Naranjo
Jun 25, 1992·Nucleic Acids Research·C J FrégeauR C Bleackley
Sep 1, 1991·European Journal of Biochemistry·F Mollinedo, J R Naranjo
Feb 7, 2013·Journal of Cancer·Michael Bordonaro
Nov 1, 1992·Critical Reviews in Oncology/hematology·M A Lea
Aug 27, 2003·The Journal of Biological Chemistry·Daniel M FassRichard H Goodman
Feb 24, 2021·Molecular Biology Reports·Marina Trombetta-LimaMari C Sogayar

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