Unusual case of dasatinib-associated acute bilateral hyphemas leading to blindness in a patient with chronic myeloid leukaemia

BMJ Case Reports
Sandhya SharmaCristina M Ghiuzeli

Abstract

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder with an incidence of 1-2 cases per 100 000 adults per year.1 Since the International Randomized Study of Interferon and STI571 trial (IRIS trial) in 2003, treatment with tyrosine kinase inhibitors (TKIs) has become the standard of care for patients with newly diagnosed CML in the chronic phase.2 Dasatinib is a second-generation TKI and is generally well tolerated, with cytopenias, gastrointestinal (GI) symptoms and fluid retention being the most commonly observed side effects.3-5 Bleeding complications, although unusual, have been reported with dasatinib, with an incidence ranging from 8% to 24%.3-6 The most commonly reported site of bleeding is the GI tract.3 5 We report an unusual case of dasatinib-associated bleeding presenting with acute bilateral hyphemas, which, to our knowledge, is the first report of its kind.

References

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Mar 15, 2003·The New England Journal of Medicine·Stephen G O'BrienUNKNOWN IRIS Investigators
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Sep 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jorge E CortesCarlo Gambacorti-Passerini
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Oct 28, 2016·Drug Design, Development and Therapy·Dilek KeskinAhmet Emre Eskazan
Aug 20, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna KreutzmanCecilia Muñoz-Calleja

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Citations

Apr 1, 2021·Drugs·Blake H FortesLauren A Dalvin

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