Abstract
Three patients with an unusual type of presenile dementia were studied. Atypical clinical pictures emerged from an evaluation of these cases. Their symptoms and signs were thought to be neither those of Alzheimer's disease nor those of Pick's disease but a partial mixture of those of both diseases. The neuropathological changes were characteristic and the common findings were as as follows: the absence of senile plaques, the widespread presence of numerous neurofibrillary tangles, a calcareous deposition of Fahr's type, a circumscribed cerebral atrophy in the temporal or/and frontal lobes, a moderate or severe demyelination and fibrous gliosis in the white matter of the atrophied areas, and a slight or moderate neuronal loss in the nucleus basalis of Meynert. Similar cases reported previously were reviewed.
References
Nov 15, 1976·Acta Neuropathologica·K KosakaA Hori
Mar 15, 1978·Acta Neuropathologica·H Shibayama, J Kitoh
Nov 1, 1978·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·M OdaH Endo
Mar 1, 1976·Neurology·H L KlawansL Simon
Mar 1, 1976·Brain : a Journal of Neurology·D R CrapperS Quittkat
Jan 1, 1968·Journal of Neuropathology and Experimental Neurology·M AdachiB W Volk
Jul 26, 1968·Science·C J GibbsW B Matthews
Nov 1, 1968·Neurology·M D Muenter, J P Whisnant
Jan 1, 1966·Psychiatria Et Neurologia·G Pilleri
Jan 1, 1983·Acta Neuropathologica·T ArendtA Tennstedt
Mar 5, 1982·Science·P J WhitehouseM R Delon
Aug 1, 1981·Annals of Neurology·P J WhitehouseM R DeLong
Apr 1, 1954·Journal of Neuropathology and Experimental Neurology·G A JERVIS
Jan 1, 1954·Archiv für Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie·W KLAGES
Oct 1, 1956·Journal of Neuropathology and Experimental Neurology·U T SLAGER, J A WAGNER
Sep 1, 1961·Archives of Neurology·R L FRIEDEE W MACK
Sep 1, 1962·Archives of Neurology·A HIRANO, H M ZIMMERMAN
May 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·R M NORMAN, H URICH
Apr 1, 1949·Archives of Neurology and Psychiatry·L BERLIN
Jul 1, 1949·Journal of Neuropathology and Experimental Neurology·M A NEUMANN
Jun 1, 1947·The Journal of Clinical Endocrinology and Metabolism·I S SIGLIN, L M EATON
Citations
Jan 1, 1992·Acta Neuropathologica·M XuK Nokura
Jun 7, 2005·Acta Neuropathologica·Judit MiklossyPatrick L McGeer
Jun 21, 2005·Acta Neuropathologica·Kuniaki TsuchiyaHaruhiko Akiyama
Jul 3, 2009·Psychiatry and Clinical Neurosciences·Katsuyuki UkaiNorio Ozaki
Oct 9, 2013·Orphanet Journal of Rare Diseases·Shafaq SaleemMuhammad Asim Khan Rehmani
Jun 20, 2014·Brain Pathology·Christer Betsholtz, Annika Keller
Jul 16, 2015·Psychiatry and Clinical Neurosciences·Katsuyuki Ukai, Kenji Kosaka