Unusual chromosome abnormalities in primary central nervous system lymphoma

Leukemia & Lymphoma
H Zattara-CannoniA M Vagner-Capodano

Abstract

Primary central nervous system (PCNS) lymphoma is a relatively rare disease. The Epstein-Barr virus (EBV) has often been implicated in the development of lymphomas. Few cytogenetic. studies on PCNS lymphomas have been reported. We describe here an unusual case of PCNS B cell lymphoma, centroblastic polymorphic type without coexistent immune deficiency. The cytogenetic study showed unusual abnormalities: t(l;9) (q25;p21); del (6) (q14 q25), trisomy 12 and in addition one clone with trisomy 7 and loss of chromosome X. We did not observe any chromosome 14 abnormality, which is more commonly reported in PCNS lymphomas.

References

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Citations

Dec 9, 1998·Cancer Genetics and Cytogenetics·H Zattara-CannoniA M Vagner-Capodano
Feb 28, 2007·Oncogene·S A KamranvarM G Masucci
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bettina GruhneMaria G Masucci

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