PMID: 6984011Jan 1, 1982Paper

Unusual distribution of Ia-like antigens on canine lymphocytes

Immunogenetics
H J DeegR Storb

Abstract

The murine monoclonal antibody 7.2, specific for a framework determinant of human Ia antigens, cross-reacts with canine cell membranes recognizing a bimolecular complex (29,000 and 34,000 daltons) similar to that described in man. We investigated the distribution of these Ia-like antigens on mononuclear cells in peripheral blood, thoracic-duct lymph, marrow, alveolar lavage fluids, lymph nodes, and thymuses from normal dogs. By complement-mediated cytotoxicity and indirect immunofluorescence, virtually all lymphocytes expressing surface immunoglobulin (B lymphocytes), monocytes/macrophages, dendritic cells, and many thymus-epithelial cells were Ia-positive. Furthermore, most non-B-lymphocytes in peripheral blood, thoracic-duct lymph, and lymph nodes expressed Ia antigens. Alveolar (T) lymphocytes and most thymocytes were Ia-negative. Generally, fluorescence intensity was higher on monocytes/macrophages and B lymphocytes than on non-B-lymphocytes. In mixed leukocyte cultures and concanavalin A-induced blastogenesis assays, treatment of responder cells with antibody 7.2 and complement abolished proliferation. Proliferative responses could not be restored by adding untreated accessory cells, indicating that cytolytic treatment had...Continue Reading

References

Jul 1, 1976·The Journal of Experimental Medicine·R E HumphreysJ L Strominger
Jan 1, 1976·Transplantation Reviews·S E CullenS G Nathenson
Oct 7, 1976·The New England Journal of Medicine·F H Bach, J J van Rood
Jan 1, 1977·Scandinavian Journal of Immunology·D SnaryM J Crumpton
Dec 1, 1973·The Journal of Experimental Medicine·D H Sachs, J L Cone
Apr 1, 1971·Transplantation·J W Templeton, E D Thomas
Jan 1, 1981·Acta Neuropathologica·S KrakowkaA Koestner
Mar 1, 1981·Human Immunology·H A VaughanA Ting
Jan 1, 1981·The Journal of Experimental Medicine·M KamounR C Nowinski
May 1, 1981·Transplantation·M Michaelides, I F McKenzie
Jan 1, 1980·The Journal of Experimental Medicine·D T YuH G Kunkel
Jan 1, 1981·Journal of Immunological Methods·R G MillerG B Price
Jan 1, 1982·Immunogenetics·H M VriesendorpD W van Bekkum
Jun 1, 1982·Transplantation·J C WulffR Storb

❮ Previous
Next ❯

Citations

Jan 1, 1987·Veterinary Research Communications·M J Day, W J Penhale
Oct 1, 1991·Annals of Hematology·J HahnE Holler
Jul 1, 1991·Annals of Hematology·C HötzlW Wilmanns
Jan 1, 1984·Developmental and Comparative Immunology·K HálaD L Ewert
Dec 1, 1987·Veterinary Immunology and Immunopathology·J K Lunney, M D Pescovitz
Jan 1, 1993·Veterinary Immunology and Immunopathology·D P LunnW P Duffus
Sep 1, 1995·Veterinary Immunology and Immunopathology·P DirscherlA Ziesenis
Jul 1, 1994·Veterinary Immunology and Immunopathology·D P BarbisD F Antczak
Oct 1, 1990·Immunology Letters·S C ChangC Y Lin
Feb 1, 1997·Current Opinion in Immunology·P Cresswell, J C Howard
Nov 1, 1990·Tissue Antigens·B A RideoutN C Pedersen
Mar 1, 1994·Tissue Antigens·M A Holmes, D P Lunn
Dec 6, 1997·Tissue Antigens·E NeunerH J Kolb
Sep 7, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Haluk OzparlakAtilla Arslan
Jan 1, 1984·Immunogenetics·M J van der Feltz, H L Ploegh
Sep 1, 1994·Transplant Immunology·R Huss, H J Deeg
May 1, 1990·Clinical Immunology and Immunopathology·M TeichnerH Grosse-Wilde
Jan 1, 1997·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J DarbèsW Hermanns
Feb 1, 1986·Tissue Antigens·R F DoverenW A Buurman

❮ Previous
Next ❯