PMID: 9550310Apr 29, 1998Paper

Unusual expression of S-100 protein in histiocytic neoplasms

Journal of Cutaneous Pathology
M M Tomaszewski, G P Lupton

Abstract

Twenty-nine cases of histiocytic neoplasms, some resembling juvenile xanthogranuloma (JXG) and others resembling reticulohistiocytoma (RH), were evaluated. Immunohistochemical stains were performed. In this series, seven cases were identified that expressed S-100 protein positive cells. The S-100 positive cells were predominantly large mononuclear and multinucleated histiocytes with eosinophilic cytoplasm, but also in some cases xanthomatous cells and Touton giant cells. These cells also expressed a positive reaction for vimentin, KP-1, and Factor XIIIa. There was no reactivity observed for monoclonal antibody 010(CD1a). A positive reaction for S-100 protein is conventionally accepted as a useful differentiating feature between histiocytosis X and non-X histiocytosis such as JXG and RH. The conflicting results of the immunohistochemical stains in the lesions we studied could be potential pitfalls in diagnosing histiocytic neoplasms.

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Citations

Dec 12, 2001·International Journal of Dermatology·J Abulafia, R A Vignale
Jun 28, 2000·The American Journal of Dermatopathology·K J BusamA A Jungbluth
Aug 2, 2001·The American Journal of Dermatopathology·S E ChangJ K Koh
Oct 3, 2002·The American Journal of Dermatopathology·Thomas BrennPhillip H McKee
May 29, 2004·Journal of Pediatric Hematology/oncology·Takuya NakataniShinsaku Imashuku
Feb 8, 2006·Journal of Pediatric Hematology/oncology·Regina DölkenJames F Beck
Nov 13, 2009·Cornea·Martin HermelAndreas Remky
May 12, 2010·Cornea·Justin M KanoffFrederick A Jakobiec
Aug 20, 2009·Pediatric Dermatology·Yosuke YamamotoYouichi Nishimura
Mar 29, 2014·BMC Research Notes·Laura PajazitiArtina Pajaziti
Feb 14, 2012·Annales de dermatologie et de vénéréologie·M AmouriH Turki
Apr 24, 2007·Journal of Cutaneous Pathology·Ashley G PernaJon A Reed
Dec 15, 2010·Journal of Cutaneous Pathology·Elgida Radoncipi VolpicelliArturo P Saavedra
Jun 26, 2013·International Journal of Dermatology·Giuseppe StincoPasquale Patrone
May 20, 2011·Journal of Cutaneous Pathology·Andrea A D'AuriaGene Kim
Jul 1, 2017·Photodermatology, Photoimmunology & Photomedicine·Alessia PacificoLuca Muscardin
Sep 19, 2017·Journal of Cutaneous Medicine and Surgery·Paul B Medline
Dec 31, 1998·Journal of Cutaneous Pathology·N S McNutt
Aug 24, 2005·Journal of Cutaneous Pathology·Gudrun RatzingerBernhard Zelger
Jul 6, 2019·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Atif SaleemTeri Longacre
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Apr 4, 2001·The American Journal of Dermatopathology·M D KrausC D Fletcher
Feb 26, 2021·Curēus·Andrew S FischerSylvia Hsu

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