PMID: 3769453Jan 1, 1986Paper

Unusual features of the T-cell receptor C domains are revealed by structural comparisons with other members of the immunoglobulin superfamily

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
D Beale, J Coadwell

Abstract

The amino acid sequences of the domains of human, mouse and rabbit T-cell antigen receptors have been aligned with those of immunoglobulin domains of known three-dimensional structure. Computerized secondary structure predictions have been performed on the sequences and putative models of the domains have been constructed. The receptor V alpha and V beta domains are closely related to immunoglobulin VH domains. The receptor C alpha domain shows some major divergences from immunoglobulin C domains and the C beta domain displays an unusual feature. The implications for T-cell receptor function are discussed.

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Citations

Jan 1, 1993·Archives of Insect Biochemistry and Physiology·R J NachmanW F Haddon
Apr 28, 1995·Molecular and Cellular Endocrinology·K SpittaelsJ Van Beeumen
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S F SchluterJ J Marchalonis
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J MarchalonisA B Edmundson
Jun 1, 1992·The Journal of Experimental Medicine·E A NalefskiA Rao

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