PMID: 12959382Sep 10, 2003Paper

Unusual IgM-secreting multiple myeloma in a dog

Journal of the American Veterinary Medical Association
Sarah J LautzenhiserRobert L Goring

Abstract

A 4-year-old castrated male dog was evaluated because of multiple-limb lameness. Signs of pain were elicited during palpation of the regions of the proximal tibial metaphyses and distal left radial diaphysis. Radiography revealed osteolytic lesions of the long bones. Blood analyses revealed hypercalcemia and transient cytopenias. Serum protein electrophoresis did not reveal a monoclonal gammopathy; however, urine protein electrophoresis revealed Bence Jones proteinuria. Serial diagnostic sampling of bone lesions, immunohistochemical staining methods, and serum and urine protein immunoelectrophoresis were required to establish a diagnosis of multiple myeloma. Two IgM components were identified via serum protein immunoelectrofixation. The dog improved clinically after initiation of chemotherapy with melphalan and prednisone; however, the dog ultimately was euthanatized because of pathologic fracture. The case was unique because there was lack of vertebral involvement, an unusual gammopathy, and difficulty in identifying myeloma cells via serial sampling.

References

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Citations

Oct 26, 2010·Veterinary Clinical Pathology·Davis M SeeligPaul R Avery
Jun 30, 2009·Journal of Medical Primatology·Susanne MauelAchim D Gruber

Related Concepts

Blood Protein Electrophoresis
Marrow
Bone Marrow Cells
Differential Diagnosis
Dog Diseases
Canis familiaris
IgM2
Immunocytochemistry
Lameness, Animal
Medphalan

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