Unusual in vitro formation of cyst-like structures associated with human intestinal spirochaetosis

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J O Gebbers, H P Marder

Abstract

Spirochaetes were isolated from rectal biopsies of three patients and successfully cultured. Enzymatic reactions and electron microscopy revealed spirochaetes resembling Brachyspira aalborgi. Examination of ultrathin sections of centrifugates of cultured spirochaetes yielded unusual cyst-like structures with an outer double membrane containing spirochaetes in different developmental stages. The protoplasmic cylinders seemed to originate from a large electron-dense focus in the cyst-like structures. The axial fibrils occurred as loosely distributed solitary structures in the cyst-like structures. Cysts were not found in the biopsy tissue. The encystment of the spirochaetes could be related to their protection, multiplication, spread and transmission.

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Citations

Sep 27, 2008·Journal of Neuroinflammation·Judith MiklossyPatrick L McGeer
Apr 1, 2009·Emerging Infectious Diseases·Eric J NelsonAndrew Camilli
Jan 1, 1994·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·V Wolf, J Wecke

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