PMID: 9541650Apr 29, 1998Paper

Unusual insertion element polymorphisms in the promoter and terminator regions of the mucAB-like genes of R471a and R446b

Mutation Research
O I KulaevaR Woodgate

Abstract

We have previously identified umu-complementing genes on two incL/M plasmids, R471a and R446b (C. Ho et al., J. Bacteriol., 175 (1993) 5411-5419). Molecular analysis of these genes revealed that they are more structurally and functionally related to mucAB from the incN plasmid pKM101 than to other members of the previously identified Umu-like family. As a consequence, we have termed these new homologs mucAB(R471a) and mucAB(R446b) respectively. Interestingly, while the location of the mucAB-like genes is essentially the same in both R471a and R446b, the regions immediately flanking the mucAB-like genes are highly polymorphic. For example, 5' to mucAB(R471a) we found an insert that appears to be a novel retroelement encoding a putative reverse transcriptase (RT). This RT is related to the reverse transcriptases encoded by group II introns but is embedded in a retron-like context. Immediately 3' to the mucAB(R471a) locus is a putative insertion element of a sparsely-dispersed class not previously reported from enteric bacteria. Both the RT and insertion element are absent in R446b. These observations suggest that the mucAB-like genes from R471a and R446b are located within regions of the R-plasmids that perhaps were once (or stil...Continue Reading

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Citations

Dec 7, 2000·Mutation Research·W H KochR Woodgate
Dec 3, 2002·Gene·Nicolás ToroManuel Fernández-López
May 9, 2001·Mutation Research·R Woodgate
Dec 3, 2004·Applied and Environmental Microbiology·Gayle C FosterGeorge W Sundin
Sep 15, 2000·Journal of Bacteriology·D R EdgellD A Shub
Feb 13, 2001·Journal of Bacteriology·D M GalliD J Leblanc
Sep 1, 2015·PLoS Genetics·Andrew RobinsonAntoine M van Oijen
Sep 23, 1998·Journal of Molecular Biology·J P McDonaldR Woodgate
Dec 21, 2000·Molecular Microbiology·F Martínez-Abarca, N Toro

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