PMID: 6408168Jul 1, 1983Paper

Unusual pattern of surface marker expression on peripheral lymphocytes from aged humans suggestive of a population of less differentiated cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
H M HallgrenJ J O'Leary

Abstract

Monoclonal antibodies were used to detect the surface antigens T3, T4, T8, and T10 on the peripheral blood lymphocytes of 26 aged (14 female and 12 male, mean age 89) and 28 young (14 female and 14 male, mean age 29) subjects. In the aged subjects, independent of the sex of the donor, the sum of the percent or absolute number of T4- and T8-positive cells was significantly greater than the number of T3-positive cells (p less than 0.001). There was also a significant increase in the percent and absolute number of cells positive for the T10 antigen with age (p less than 0.01). Analysis of individual cell surface markers revealed that the percent and absolute number of T3-positive cells was decreased only in old females, with no difference between old males and the young donors. The expression of T4 was not affected by age or sex, but both the percent and absolute number of T8-positive cells were decreased in females relative to males, with no effect due to age. These findings are consistent with the presence of a population of peripheral T cells in advanced age with a thymocyte-like pattern of surface marker expression. This conclusion is supported by previous work showing a less differentiated pattern of LDH isoenzyme distributio...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved