Unusual presentation of a skull base mass lesion in sarcoidosis mimicking malignant neoplasm: a case report

BMC Neurology
Katsunori ShijoAtsuo Yoshino

Abstract

Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis in children is even rarer whether it is systemic or not. We described the case of a 12-year-old boy who presented with monocular vision loss accompanied by unusual MRI features of an extensive meningeal infiltrating mass lesion. The patient underwent surgical resection (biopsy) via a frontotemporal craniotomy to establish a definitive diagnosis based on the histopathology, since neurosarcoidosis remains a very difficult diagnosis to establish from neuroradiogenic imagings. Based on the histopathology of the resected mass lesion, neurosarcoidosis was diagnosed. On follow-up after 3 months of steroid therapy, the patient displayed a good response on the imaging studies. MRI revealed that the preexisting mass lesion had regressed extremely. We also conducted a small literature review on imaging studies, manifestations, appropriate treatments, etc., in particular neurosarcoidosis including children. Although extremely rare, neurosarcoidosis, even in children, should be considered in the differential diagnosis of skull base mass...Continue Reading

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Citations

Jul 14, 2020·The Annals of Otology, Rhinology, and Laryngology·Jason R CrossleyMichael Hoa
Jan 20, 2021·BMJ Case Reports·Iman Usama HosniNeil Opie
May 1, 2021·Journal of Investigative Medicine High Impact Case Reports·D Sofia Villacis-Nunez, Amit Thakral
Aug 20, 2021·Advances in Radiation Oncology·Anthony C CasperJaden D Evans

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Methods Mentioned

BETA
X-ray
surgical resection
biopsy

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