PMID: 6413386Jan 1, 1983Paper

Unusual response to bifunctional alkylating agents in a case of Fanconi anaemia

Human Genetics
M L KweeH Joenje

Abstract

Chromosomal breakage frequencies were determined in Fanconi anaemia (FA) blood cultures treated with various concentrations of the polyfunctional alkylating agents mitomycin C, diepoxybutane, and cis-platinum(II)-diammine-dichloride, for which FA cells have a characteristic hypersensitivity. At concentrations that hardly affected control cultures, three out of four patients tested exhibited a concentration-dependent increase of cells with aberrant chromosomes, with a concomitant increase in the number of chromosomal aberrations per aberrant cell. The fourth patient, a 22-year-old male, was exceptional because with all three clastogens only 40% of his cultured cells exhibited a typical concentration-dependent response, while 60% of his cells responded like those from normal healthy controls. The possible nature and significance of this unusual response is discussed.

References

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Citations

Mar 1, 1994·Stem Cells·C C dos SantosM Buchwald
Nov 1, 1990·Somatic Cell and Molecular Genetics·M Z ZdzienickaJ W Simons
Mar 1, 1987·Cancer Genetics and Cytogenetics·H JoenjeK J Roozendaal
Jul 15, 1988·Cancer Genetics and Cytogenetics·J Rosendorff, R Bernstein
Sep 1, 1993·British Journal of Haematology·B P Alter
Dec 1, 2011·Balkan Journal of Medical Genetics : BJMG·S CirkovicA Jovanovic
Feb 6, 2016·Journal of the National Cancer Institute·Miguel A Villalona-CaleroCynthia Timmers
Jun 14, 2012·Anemia·Anneke B OostraJohan P de Winter
Feb 26, 2004·Radiation Research·Reinhard KalbDetlev Schindler
Oct 21, 1998·American Journal of Medical Genetics·H JoenjeH Hoehn
Jan 9, 2003·Cancer·Blanche P Alter
Oct 3, 2002·Nature Reviews. Genetics·Hagop Youssoufian, Reed E Pyeritz
Jun 5, 2001·Nature Reviews. Genetics·H Joenje, K J Patel
Sep 14, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Raghuprasad Varma
Oct 1, 1996·American Journal of Hematology·B P Alter
May 6, 2017·British Journal of Haematology·Carlo Dufour
Apr 26, 2005·The Journal of Biological Chemistry·Woo-Hyun ParkJeffrey D Parvin
Jul 15, 2021·British Journal of Haematology·Andrew D Hughes, Peter Kurre

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