Unusual soft tissue infiltrates with 18F-FDG uptake in a patient with hairy cell leukemia

Clinical Nuclear Medicine
Glenna M GibsonPaul Thomas

Abstract

Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder, representing approximately 2% of leukemias. Diagnostic features include pancytopenia, splenomegaly, bone marrow reticulin fibrosis, and circulating hairy cells. Less commonly, there may be involvement of the liver and lymph nodes. We present a case of a 53-year-old man with HCL who was found to have soft tissue masses within the mediastinum and neck during pretreatment workup. An F-FDG PET/CT scan was requested to assess these lesions before treatment. These extensive infiltrates were FDG avid, and core biopsy of the mediastinal tissue was undertaken. Results were consistent with HCL.

References

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Citations

Mar 15, 2016·Clinical Nuclear Medicine·Zhanli FuQian Li
Aug 7, 2020·European Journal of Haematology·Pawel RobakTadeusz Robak

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