Unusually rapid beta-cell failure in a patient newly diagnosed with type 2 diabetes presenting acutely with unprovoked severe hyperglycaemic hyperosmolar state: a case report.

Cases Journal
Joey YeohKenneth Ross Muir

Abstract

Pancreatic beta-cell failure on a background of insulin resistance results in the inability to compensate for fasting hyperglycaemia and eventually produces type 2 diabetes mellitus. We describe an interesting case of a patient who presented acutely with unprovoked severe hyperglycaemic hyperosmolar state and was subsequently diagnosed with type 2 diabetes mellitus on a background of only impaired first phase insulin secretion 4 months prior. Glucagon stimulation test detected significant beta-cell failure necessitating long term exogenous insulin therapy which is highly unusual by virtue of the rapid apparent deterioration.

References

Jul 11, 2006·The Journal of Clinical Investigation·Marc Prentki, Christopher J Nolan
Oct 13, 2006·European Journal of Clinical Investigation·F Guerrero-Romero, M Rodríguez-Morán
Mar 14, 2007·Endocrine Reviews·Bernardo L Wajchenberg
Jan 10, 2008·Diabetes Care·UNKNOWN American Diabetes Association
Jul 16, 2008·Current Diabetes Reports·Cristina LencioniStefano Del Prato

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