Unveiling molecular mechanisms of pneumococcal surface protein A interactions with antibodies and lactoferrin

Clinica Chimica Acta; International Journal of Clinical Chemistry
Mark J Jedrzejas

Abstract

Streptococcus pneumoniae is a Gram-positive bacterium and a major human pathogen. The organism displays on its surface a variety of molecules that are involved in many essential processes including interactions with the tissues and molecules of its human host. A number of such surface molecules are essential virulence factors in disease processes and pathogenesis during all stages of bacterial life. Here we introduce one such surface protein, pneumococcal surface protein A (PspA), and show its molecular and structural aspects, and underlying mechanism of function at the atomic level as currently understood. The basis of its anti-complementary properties and functional interactions with its ligand, lactoferrin, is discussed. The PspA antigen binding to lactoferrin prevents the bactericidal effect of this human molecule of many functions. This review is focused on new function characterization studies performed during this century (year 2001 and later). Earlier studies on PspA were reviewed by this author in 2001 and 2004 [Jedrzejas MJ. Pneumococcal virulence factors: structure and function. Microbiol Mol Biol Rev, 2001;65:187-207; Jedrzejas MJ. Extracellular virulence factors of Streptococcus pneumoniae. Front Biosci 2004;9:891-...Continue Reading

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Jan 1, 1981·International Review of Cytology·T J Beveridge
Sep 1, 1982·Journal of Bacteriology·R LopezA Tomasz
Jan 1, 1997·Society for Applied Bacteriology Symposium Series·T J MitchellP W Andrew
Jan 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·D E BrilesM J Crain
Apr 9, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J L GarcíaR López
Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·X L SunE N Baker
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·G B JamesonE N Baker
Jan 6, 2000·Archives of Biochemistry and Biophysics·M J JedrzejasE Lamani
Sep 19, 2000·Infection and Immunity·K K GosinkH R Masure
Dec 29, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·H M BakerE N Baker
Apr 9, 2001·Infection and Immunity·A HåkanssonD E Briles
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·M J Jedrzejas
Jun 20, 2001·The Journal of Biological Chemistry·M J JedrzejasR S Becker
Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J DopazoJ F García-Bustos
Sep 7, 2001·Journal of Bacteriology·J HoskinsJ I Glass
Nov 6, 2001·Nature Structural Biology·C Fernández-TorneroA Romero
Oct 22, 2003·Molecular Immunology·Sebastien Farnaud, Robert W Evans
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Mark J Jedrzejas

❮ Previous
Next ❯

Citations

Nov 17, 2010·Archives of Otolaryngology--head & Neck Surgery·Patricia A SchachernSteven K Juhn
Sep 23, 2006·Expert Review of Vaccines·Sandra ThomasSuresh Mahalingam
Jul 1, 2015·The Journal of Infectious Diseases·Ryuta UrakiYoshihiro Kawaoka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.