Unveiling the Aggregation Behavior of Doxorubicin Hydrochloride in Aqueous Solution of 1-Octyl-3-methylimidazolium Chloride and the Effect of Bile Salt on These Aggregates: A Microscopic Study

Langmuir : the ACS Journal of Surfaces and Colloids
Arghajit PyneNilmoni Sarkar

Abstract

In this article, we have unveiled the aggregation behavior of a potent chemotherapeutic drug, doxorubicin hydrochloride (Dox) in a well-known imidazolium based surface active ionic liquid (SAIL), 1-octyl-3-methylimidazolium chloride (C8mimCl). The aggregates formed by Dox in C8mimCl have been characterized using dynamic light scattering (DLS), fluorescence lifetime imaging microscopy (FLIM), high-resolution transmission electron microscopy (HR-TEM), analytical transmission electron microscopy (analytical TEM), field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), and Fourier-transform infrared spectroscopy (FTIR) measurements. It is found that Dox forms large spherical aggregates in the presence of C8mimCl SAIL. We have also explored the driving force behind this aggregation behavior of Dox in C8mimCl. Furthermore, it is observed that in the presence of a common bile salt, sodium cholate (NaCh), Dox/C8mimCl spherical aggregates disrupt to form rodlike fibrillar aggregates. Therefore, formation of spherical aggregates and also its disruption into rodlike fibrillar aggregates have been performed, and this is expected to open a new scope for the design of a new generation smart drug delivery system wh...Continue Reading

References

Nov 1, 1995·Biochimica Et Biophysica Acta·D D LasicY Barenholz
Aug 5, 1994·Journal of Molecular Biology·Z S DerewendaP M Kobos
Dec 22, 1998·Biochimica Et Biophysica Acta·X LiW R Perkins
Dec 22, 1999·Archives of Internal Medicine·A F Hofmann
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·G BaneyxV Vogel
May 31, 2003·Nature Materials·Kenneth R Seddon
Apr 20, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·James BowersRichard K Heenan
Nov 16, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Martin AnderssonAnders E C Palmqvist
Aug 4, 2006·The Journal of Physical Chemistry. a·Kun DongXiaoqian Yao
Mar 19, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Lingxiang JiangJianbin Huang
Oct 22, 2008·Advances in Colloid and Interface Science·Dominique Langevin
Nov 29, 2008·Advances in Colloid and Interface Science·Ilja K VoetsMartien A Cohen Stuart
Dec 22, 2009·Chemical Communications : Chem Comm·Lydie ViauAndré Vioux
Jun 10, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Jie YuanLiqiang Zheng
Nov 5, 2011·Journal of the American Chemical Society·Immanuel Willerich, Franziska Gröhn
Nov 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Shasha SongJingcheng Hao
Sep 18, 2012·Journal of Photochemistry and Photobiology. B, Biology·Susithra Selvam
Oct 4, 2012·Journal of the American Chemical Society·Carlos R López-BarrónNorman J Wagner
Nov 14, 2012·Chemical Reviews·A Subha Mahadevi, G Narahari Sastry
Feb 12, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Qingmin JiKatsuhiko Ariga
Apr 13, 2013·Physical Chemistry Chemical Physics : PCCP·Ying HuaDimitra Markovitsi
May 7, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Yingqiu GuLiqiang Zheng
Jul 16, 2013·International Journal of Pharmaceutics·Zoltán FülöpThorsteinn Loftsson
Aug 7, 2013·Chemical Communications : Chem Comm·K Srinivasa RaoArvind Kumar
Mar 19, 2014·The Journal of Physical Chemistry. B·Soheila JavadianAfshin Asadzadeh Shahir
Mar 29, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Huiyong WangSuojiang Zhang
May 27, 2014·Accounts of Chemical Research·Wade W Grabow, Luc Jaeger
May 29, 2014·Chemical Communications : Chem Comm·Na DuRenjie Zhang
Mar 24, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·M HausteinP Schiller
Jul 2, 2015·Physical Chemistry Chemical Physics : PCCP·Kiki A KurniaMara G Freire
May 24, 2016·Nature Materials·R MolinaroE Tasciotti
Aug 27, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Jinglin ShenShiling Yuan
Dec 10, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Patrick DrückerHans-Joachim Galla
Jan 27, 2017·Chemical Reviews·Ksenia S EgorovaValentine P Ananikov
Aug 26, 2017·Journal of the American Chemical Society·Ruizi PengWeihong Tan

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Feb 20, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Sourav NandiNilmoni Sarkar
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Huifang Zhang, Peng Liu

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