Unveiling the pitfalls of the protein corona of polymeric drug nanocarriers.

Drug Delivery and Translational Research
Germán BerrecosoMaría José Alonso

Abstract

The protein corona is a natural protein layer spontaneously formed around nanomaterials when exposed to biological media. This layer can alter the nanosystems' biological performance, particularly their tissue accumulation, cellular uptake, clearance by the immune system, toxicity, and even the release profile of their payloads. Hence, the characterization of this protein layer has become a critical step when developing a new nanomedicine. The modification of the nanosystem fate by the protein corona, systematically ignored in the vast majority of the nanotechnology-based research, may have contributed to the low in vitro/in vivo correlation. Actually, the protein corona of polymeric nanosystems has been scarcely studied in the literature, and most studies have been focused instead on metallic nanoparticles and liposomes. In this review, we analyzed the influence of the physicochemical properties and composition of the polymeric nanosystems on the protein layer deposited around them. In addition, we present some recommendations on how to perform the protein corona studies of polymeric nanoparticles, which, hopefully, will contribute to obtain more reliable and reproducible data in the future. Graphical abstract.

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Citations

Sep 7, 2020·Journal of Nanobiotechnology·Estefânia V R CamposLeonardo Fernandes Fraceto
Feb 9, 2021·Emergent Materials·Abhimanyu TharayilNandakumar Kalarikkal
Feb 2, 2021·Drug Delivery and Translational Research·Federico QuattriniMaría José Alonso
Dec 18, 2020·Frontiers in Molecular Biosciences·Alex Bunker, Tomasz Róg
Feb 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Carlos E de CastroFernando C Giacomelli
Mar 2, 2021·Journal of Drug Targeting·Jennifer Thayanne Cavalcante de AraújoMarlus Chorilli
Jan 29, 2021·ChemMedChem·Marta GozziEvamarie Hey-Hawkins
Apr 24, 2021·Drug Discovery Today·Anna E CaprificoGianpiero Calabrese
Jun 15, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·B Halamoda-KenzaouiF Caputo
Jul 1, 2021·Nanomedicine·Ahmed S AbdElhamidAhmed O Elzoghby

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Methods Mentioned

BETA
size exclusion chromatography
electrophoresis

Software Mentioned

ImageJ
MASCOT

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