Unwebbing the presynaptic web

Neuron
P L Zamorano, C C Garner

Abstract

The release of neurotransmitter from nerve terminals occurs at a specialized region of the presynaptic plasma membrane called the active zone. A dense matrix of proteins associated with the active zone, called the presynaptic web, is thought to play a fundamental role in defining these neurotransmitter release sites. In this issue of Neuron, Phillips et al. have identified conditions for the biochemical purification of the presynaptic web and show that the web is comprised of proteins involved in the docking, fusion, and recycling of synaptic vesicles.

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Citations

Jun 19, 2003·Molecular and Cellular Neurosciences·Thomas DresbachEckart D Gundelfinger
Apr 10, 2007·Annual Review of Neuroscience·A Kimberley McAllister
Mar 29, 2013·Autonomic Neuroscience : Basic & Clinical·Raj K Goyal, Arun Chaudhury
Aug 14, 2003·Biochimica Et Biophysica Acta·Alison K Gillingham, Sean Munro
Mar 15, 2006·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Tracie A BarnettJim Hanley

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