Up on the tightrope: natural killer cell activation and inhibition.

Nature Immunology
Lewis L Lanier

Abstract

Natural killer (NK) cells circulate through the blood, lymphatics and tissues, on patrol for the presence of transformed or pathogen-infected cells. As almost all NK cell receptors bind to host-encoded ligands, signals are constantly being transmitted into NK cells, whether they interact with normal or abnormal cells. The sophisticated repertoire of activating and inhibitory receptors that has evolved to regulate NK cell activity ensures that NK cells protect hosts against pathogens, yet prevents deleterious NK cell-driven autoimmune responses. Here I highlight recent advances in our understanding of the structural properties and signaling pathways of the inhibitory and activating NK cell receptors, with a particular focus on the ITAM-dependent activating receptors, the NKG2D-DAP10 receptor complexes and the CD244 receptor system.

References

Oct 1, 1993·The Journal of Experimental Medicine·N M Valiante, G Trinchieri
Aug 4, 1998·The Journal of Experimental Medicine·D D BilladeauP J Leibson
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J D SchatzleV Kumar
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S G TangyeK E Nichols
Oct 6, 2000·Science·J V Ravetch, L L Lanier
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C WatzlE O Long
Feb 13, 2001·Molecular Immunology·S G TangyeJ H Phillips
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·R PaoliniA Santoni
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BouchonM Colonna
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S S ChuangP A Mathew
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire L SutherlandDavid Cosman
Feb 12, 2002·Nature Immunology·Francesco ColucciJames P Di Santo
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer KlemJohn D Schatzle
Nov 12, 2002·Nature Immunology·Susan GilfillanMarco Colonna
May 13, 2003·Nature Immunology·Daniel D BilladeauPaul J Leibson
May 13, 2003·Nature Immunology·Simona ZompiFrancesco Colucci
Aug 15, 2003·Molecular and Cellular Biology·Christopher C StebbinsEric O Long
Mar 30, 2004·European Journal of Immunology·Pascale AndréPascale Paul
May 5, 2004·The Journal of Experimental Medicine·Kyung-Mi LeeVinay Kumar
Jun 1, 2004·Molecular and Cellular Biology·Riyan ChenAndré Veillette
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David B RosenLewis L Lanier
Sep 15, 2004·The Journal of Experimental Medicine·Marina CellaWojciech Swat
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Swapnil V VaidyaPorunelloor A Mathew
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren I Richie EhrlichLewis L Lanier
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ala Aoukaty, Rusung Tan
May 4, 2005·The Journal of Experimental Medicine·Nicholas D HuntingtonDavid M Tarlinton
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·David GarrityKai W Wucherpfennig

❮ Previous
Next ❯

Citations

Jul 28, 2011·Cancer Immunology, Immunotherapy : CII·Jennifer A A GubbelsJoseph Connor
Oct 12, 2013·Cancer Immunology, Immunotherapy : CII·Raúl Germán SpallanzaniNorberto Walter Zwirner
Jul 21, 2012·Seminars in Immunopathology·Qiuju HanZhigang Tian
Oct 1, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Michal PyzikSilvia M Vidal
Mar 19, 2009·Medical Molecular Morphology·Satoshi YamagiwaTakafumi Ichida
Oct 3, 2013·Journal of Neuro-oncology·Justyna KmiecikMartha Chekenya
Mar 29, 2012·Immunologic Research·Vanessa NoriegaDomenico Tortorella
Apr 30, 2013·The Journal of Microbiology·Hyosun Cho
Apr 23, 2013·Trends in Immunology·Sarah Q CromePamela S Ohashi
Apr 13, 2013·Cell Death and Differentiation·C J ChanL Martinet
Jun 28, 2011·Cellular & Molecular Immunology·Longyan WuJian Zhang
Apr 9, 2013·Cellular & Molecular Immunology·Haoyu SunWeihua Xiao
Mar 3, 2009·Cell Research·Noah S Butler, John T Harty
Nov 26, 2009·Immunology and Cell Biology·Victoria G EmpsonNicola Dalbeth
Aug 18, 2010·Immunology and Cell Biology·Antonio E SerranoMaría-Carmen Molina
Jun 23, 2010·Immunology and Cell Biology·Hollie J PegramMichael H Kershaw
Mar 6, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Katrin S ReinersElke Pogge von Strandmann
Aug 5, 2011·Nature·Galit AlterMarcus Altfeld
Mar 1, 2014·Nature Communications·Jens KieckbuschFrancesco Colucci
Oct 5, 2010·Nature Immunology·Matthew E CallJames J Chou
Jul 9, 2011·Nature Immunology·Silke Paust, Ulrich H von Andrian
Aug 21, 2012·Nature Immunology·Natalie A BezmanUNKNOWN Immunological Genome Project Consortium
Apr 22, 2008·Nature Immunology·James P Di Santo
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jul 10, 2010·Nature Reviews. Immunology·Richard A FlavellPaula Licona-Limón
Feb 26, 2011·Nature Reviews. Immunology·Marcus AltfeldNina Bhardwaj
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Noa StanietskyOfer Mandelboim
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne ChauveauDaniel M Davis
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jessica SpreuAlexander Steinle
Dec 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesca BelloraCristina Bottino
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mark T OrrLewis L Lanier
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrea Caballero BenitezThomas Spies
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandra Lopez-VergèsLewis L Lanier
Dec 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Philipp A LangPamela S Ohashi
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Juan LiuXuetao Cao
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paul J Choi, Timothy J Mitchison
Jun 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yili LiRoy A Mariuzza
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kuldeep S CheentSalim I Khakoo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.