Up-regulation of A 2B adenosine receptor in A 2A adenosine receptor knockout mouse coronary artery.

Journal of Molecular and Cellular Cardiology
Bunyen TengS Jamal Mustafa

Abstract

In this study, we looked into possible compensatory changes of other adenosine receptors (ARs) in A(2A) genetic knockout mice (A2AKO) as well as the functional role of nitric oxide (NO) in A(2A) AR-mediated vasodilation. Gene expression of ARs from coronary arteries of A(2A) AR wild type mice (A2AWT) and A2AKO was studied using real-time PCR. Functional studies were carried out in isolated heart and isolated coronary artery preparations. A(2B) AR was found to be 4.5 fold higher in A2AKO than in A2AWT, while A(2A) AR expression was absent in A2AKO. There was no difference in A(1) and A(3) ARs between WT and KO animals. The concentration-relaxation curve for adenosine-5'-N-ethylcarboxamide (NECA, non-selective AR agonist) in isolated coronary arterial rings in A2AKO was shifted to the left when compared to A2AWT. The concentration-response curve for A(2B) selective agonist (BAY 60-6583) was also shifted to the left in A2AKO hearts. L-NAME, a non-specific NO synthase inhibitor, did not affect baseline coronary flow (CF) until the concentration reached 10 microM in A2AWT (76.32+/-11.35% from baseline, n=5). In A2AKO, the CF decreased significantly by L-NAME only at a higher concentration (100 microM, 93.32+/-5.8% from baseline, n=5...Continue Reading

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Citations

Jun 15, 2013·Pharmacology & Therapeutics·John P HeadrickJason N Peart
Sep 23, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mohammed A NayeemS Jamal Mustafa
Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
Apr 20, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
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