Up-regulation of a fibroblast growth factor binding protein in children with renal diseases

Kidney International
X H LiuP E Ray

Abstract

Basic fibroblast growth factor (bFGF) is an angiogenic growth factor that is involved in renal growth and the pathogenesis of renal diseases. We have detected high levels of bFGF accumulated in the kidney of HIV-transgenic mice and in children with HIV-associated renal diseases and the hemolytic uremic syndrome (HUS). However, the mechanism modulating the activity of bFGF under these circumstances is poorly understood. We carried out experiments to determine whether a secreted binding protein (FGF-BP) that modulates the activity of bFGF during the process of tumor growth was expressed in pediatric kidneys and to define whether the expression of FGF-BP was altered in pediatric renal diseases associated with high levels of bFGF. Immunohistochemistry and in situ hybridization studies were done in 41 renal sections from children with HIV nephropathies, HUS, other pediatric renal diseases, controls, and fetal kidneys. Western blots and reverse transcriptase-polymerase chain reaction studies were done in selected urine samples and cultured renal cells. Recombinant FGF-BP was produced to study the mitogenic activity of FGF-BP in cultured human renal proximal tubular epithelial cells (RPTEcs). The expression of FGF-BP was up-regulated ...Continue Reading

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Citations

Jul 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patricio E RayAnu Puri
Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pingtao TangPatricio E Ray
Mar 17, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patricio E Ray
Jun 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Suma Bhat HoffmanPatricio E Ray
May 20, 2003·Kidney International·Patricio E RayJoseph L Bryant
May 29, 2004·AIDS·Michael J Ross, Paul E Klotman
Mar 26, 2011·Journal of the American Society of Nephrology : JASN·Maciej TomaszewskiNilesh J Samani
Apr 10, 2009·Kidney International·Angel A Soler-GarcíaPatricio E Ray
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Andreas KurtzAnton Wellstein
Sep 7, 2007·Mayo Clinic Proceedings·Thushan I de SilvaDavid H Dockrell
Dec 6, 2005·The International Journal of Biochemistry & Cell Biology·Shaker AbuharbeidAchim Aigner
Mar 13, 2015·Proteomics. Clinical Applications·Sofia PerazzoPatricio E Ray
Sep 29, 2011·The American Journal of Pathology·Elena TassiAnton Wellstein
Nov 1, 2006·Expert Review of Clinical Immunology·Michael J Ross
Sep 9, 2017·Infectious Diseases·Ankur Kumar JindalRakesh Kumar Pilania
Dec 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patricio E RayAnton Wellstein
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elena TassiAnton Wellstein
Aug 18, 2001·The Journal of Biological Chemistry·E TassiA Wellstein
Mar 4, 2006·Methods : a Companion to Methods in Enzymology·Ralf T HenkeAnton Wellstein
Jun 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patricio E RayJing Yu

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