Up-regulation of activated macrophages in response to degeneration in the taste system: effects of dietary sodium restriction

The Journal of Comparative Neurology
Lynnette Phillips McCluskey

Abstract

Dietary sodium restriction combined with unilateral chorda tympani nerve section leads to a rapid and specific decrease in neurophysiological taste responses to sodium in the contralateral, intact chorda tympani (Hill and Phillips [1994] J. Neurosci. 14:2904-2910). Previous work demonstrated that dietary sodium restriction may induce these early functional deficits by inhibiting immune activity after denervation (Phillips and Hill [1996] Am. J. Physiol. 271:R857-R862). However, little is known about the leukocyte response to denervation of taste buds in fungiform papillae. In the current study, it was hypothesized that T cells and macrophages are increased in the tongue after unilateral denervation in control-fed but not sodium-restricted animals. Adult, specified pathogen-free rats received unilateral chorda tympani nerve section or sham section followed by dietary sodium restriction or maintenance on control diet. At day 1, 2, 5, 7, or 50 postsectioning, immunostaining was used to detect the percentage of staining for activated macrophages, the number of alpha beta T cells, and the number of delta gamma epithelial T cells in the tongue. The number of lingual T cells did not significantly differ between treatment groups follow...Continue Reading

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Citations

Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nick A GuagliardoDavid L Hill
Jan 4, 2012·Journal of Neuroscience Research·Liqiao ShiLynnette Phillips McCluskey
Dec 23, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lianying He, Lynnette Phillips McCluskey
Mar 3, 2005·Journal of Neuroscience Research·Melissa Ann Cavallin, Lynnette Phillips McCluskey
Jul 13, 2007·The Journal of Comparative Neurology·Nick A Guagliardo, David L Hill
Mar 25, 2016·Journal of Neurophysiology·Devaki KumarhiaLynnette Phillips McCluskey
Nov 10, 2014·Metabolic Brain Disease·Lingbin MengRui Ji

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