Up-regulation of CatSper genes family by selenium.

Reproductive Biology and Endocrinology : RB&E
Shabnam MohammadiSeyed Javad Mowla

Abstract

CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression. Here, we investigated the effects of selenium (Se) on the expression of CatSper genes and sperm parameters in aging versus young male mice. Forty 11-13 months aging male mice and forty 2-3 months young adult male mice were used. The animals were divided in two experimental groups: first group including aging males and second group comprising of young adult males, both treated with Se. The experimental groups were injected intra-peritoneally with Se (0.2 mg/kg) daily, for up to 5 weeks. Two other groups, aging and young adult mice without Se treatment were used as controls. All the animals were rapidly sacrificed by cervical dislocation on the days 21, 28, 35 and 42 after Se treatment. Subsequently, the morphology of the collected sperms was analyzed, and one of the testes from each mouse used for semi-quantitative RT-PCR. The significancy of the data was analyzed using ANOVA. Our data revealed that there was a significant up-regulation of CatSper gen...Continue Reading

References

Feb 15, 2001·Fertility and Sterility·S A KiddA J Wyrobek
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Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Gary E OlsonRaymond F Burk
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Citations

Dec 25, 2012·Toxicology and Applied Pharmacology·Mohammad Amin RezvanfarMohammad Abdollahi
Sep 14, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Saber Abdul Ruhman SakrAmany Ebrahem Nofal
Jul 24, 2010·Chemico-biological Interactions·Olivier BarbierLuz María Del Razo
Sep 12, 2015·Journal of Assisted Reproduction and Genetics·Fangpeng ShuXiangming Mao
Oct 1, 2014·Journal of Toxicology and Environmental Health. Part a·Manivannan JothiramajayamAnita Mukherjee
Sep 24, 2016·Animal Reproduction Science·Soroush SafaHossein Janmohammadi
Feb 13, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Archana SrivastavFalgun W Bansode
Sep 28, 2018·Acta Biologica Hungarica·Fatemeh AlipourElnaz Khordad
Dec 23, 2021·Biomédica : revista del Instituto Nacional de Salud·Omid JazayeriFereshteh Mir Moammadrezaei

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Methods Mentioned

BETA
PCR
PCRs
light microscopy

Software Mentioned

CatSper3
Genrunner
Uvidoc
CatSper
CatSper s
CatSper4

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