Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis

Clinical and Experimental Immunology
Nicola CalvaniFranco Silvestris

Abstract

There is evidence that nephritis is dominated by a Th1 immune response in systemic lupus erythematosus. Since IL-18 promotes polarization of the immune response toward Th1, we investigated the role of this cytokine in lupus nephritis (LN). A total of 133 lupus patients and 44 healthy subjects were enrolled. Demographic and clinical characteristics with renal biopsy data were recorded. IL-18 along with IFN-gamma and IL-4, two prototypical of Th1 and Th2 cytokines, were measured in serum by ELISA. Peripheral blood lymphocytes were analysed by flow cytometry for IFN-gamma and IL-4. IL-18 expression was determined by immunohistochemistry in 13 renal biopsy specimens from patients with LN and 2 controls. Serum IL-18 was higher in lupus patients than in controls. Levels of IL-18 correlated with urinary microalbumin and were increased in patients with LN when compared to those without LN. IL-18 expression was also increased within the glomeruli of nephritic patients and was primarily detected within the mesangial matrix and in infiltrating mononuclear cells. Measurement of IFN-gamma and IL-4 in either sera or peripheral blood lymphocytes showed high IFN-gamma along with low IL-4 expression in LN patients compared to patients without n...Continue Reading

References

Apr 1, 1995·Immunological Reviews·D M Klinman, A D Steinberg
Apr 15, 1997·The Journal of Clinical Investigation·S L PengJ Craft
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·L ShapiroC A Dinarello
Jan 20, 1999·The Journal of Allergy and Clinical Immunology·C A Dinarello
Aug 14, 1999·Arthritis and Rheumatism·M AkahoshiY Niho
Sep 24, 1999·The Journal of Clinical Investigation·G FantuzziC A Dinarello
Oct 20, 1999·Methods : a Companion to Methods in Enzymology·C A Dinarello
Jun 29, 2000·Immunology Today·I B McInnesF Y Liew
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Guillermo Pérez DE LemaDetlef Schlöndorff
Oct 11, 2001·Arthritis and Rheumatism·K MasutaniH Hirakata
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E EsfandiariF Y Liew
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideki Miyaura, Makoto Iwata
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eriya KikawadaVicki R Kelley
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paola BossùDiana Boraschi

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Citations

Nov 15, 2011·Arthritis Research & Therapy·Ramesh SaxenaChandra Mohan
Sep 26, 2008·Journal of the American Society of Nephrology : JASN·Huiling WuSteven J Chadban
Apr 27, 2012·Autoimmune Diseases·Alberto de Zubiria Salgado, Catalina Herrera-Diaz
Aug 12, 2014·Seminars in Immunopathology·Tony N Marion, Arnold E Postlethwaite
Nov 4, 2011·Genes and Immunity·J LeeL P Kane
Oct 11, 2005·Autoimmunity Reviews·Nicola CalvaniFranco Silvestris
Dec 24, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D Marks, Kjell Tullus
Aug 19, 2007·Immunologic Research·Seetha Monrad, Mariana J Kaplan
Mar 1, 2009·Expert Opinion on Medical Diagnostics·Irene Meester, Juan Manuel Solis-Soto
Jul 2, 2015·Nephrology·Laura-Nanna LohkampTimo Siepmann
May 30, 2007·Seminars in Nephrology·Peter G Tipping, Stephen R Holdsworth
Aug 30, 2005·Annals of the New York Academy of Sciences·Marco TucciFranco Silvestris
Sep 18, 2009·Annals of the New York Academy of Sciences·Marco TucciFranco Silvestris
Sep 18, 2009·Annals of the New York Academy of Sciences·Flavia FavilliPaola Migliorini
Sep 18, 2008·Clinical and Experimental Immunology·M TucciF Silvestris
May 1, 2009·Arthritis and Rheumatism·Ji YangMing Li
Sep 26, 2007·Annals of the New York Academy of Sciences·Alyson J ManginiJean Maguire Van Seventer
Sep 14, 2006·Clinical and Experimental Immunology·M TucciF Silvestris
Sep 30, 2008·Arthritis and Rheumatism·Dong WangMiriam Wittmann
Sep 7, 2007·Annals of the New York Academy of Sciences·Marco TucciFranco Silvestris
Jul 20, 2011·The Journal of Dermatology·Naoya MikitaFukumi Furukawa
Apr 24, 2014·Arthritis & Rheumatology·J Michelle Kahlenberg, Mariana J Kaplan
Jan 23, 2014·Arthritis & Rheumatology·J Michelle KahlenbergMariana J Kaplan
Dec 4, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniel N ClarkBrian D Poole
Jan 18, 2008·The Journal of Investigative Dermatology·Fabio O SánchezMarta E Alarcón-Riquelme

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