PMID: 9543668Apr 17, 1998Paper

Up-regulation of lysozyme production in colonic adenomas and adenocarcinomas

Histopathology
S T YuenS Y Leung

Abstract

The presence of lysozyme protein in some gastric adenomas and adenocarcinomas has been well documented. There have been relatively few studies investigating the presence of lysozyme in tumours of the large intestine and they show contrasting results. We aim to investigate the cellular source and expression of lysozyme in colonic adenomas and adenocarcinomas. We randomly selected 29 and 27 colonic adenomas and adenocarcinomas, respectively. Using in-situ hybridization (ISH) and immunohistochemistry (IHC), we found an up-regulation of lysozyme in the dysplastic epithelium of all the adenomas studied, with more than 80% of cases expressing moderate to strong signals. Although the up-regulation of lysozyme was also observed in adenocarcinomas, only 30% of the cases showed moderate to strong signals, mostly with an uneven distribution. Down-regulation of lysozyme in the severely dysplastic and invasive foci were noted in some cases of adenoma with malignant transformation. Normal colonic glands were consistently negative for lysozyme at both the mRNA and the protein level, but inflamed and immature regenerative colonic epithelium at the crypt base showed positive signals in a similar pattern to those observed in the dysplastic epith...Continue Reading

References

Feb 1, 1975·Journal of Clinical Pathology·D Y Mason, C R Taylor
Dec 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Klockars, S Reitamo
Feb 20, 1975·The New England Journal of Medicine·K R FalchukK J Isselbacher
Aug 1, 1992·Gastroenterology·G W StampN A Wright
Jul 1, 1992·Gut·S A Sarker, K Gyr
Aug 1, 1989·Gastroenterology·S B HoY S Kim
Aug 14, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G M CostongsP C Janson
Jun 1, 1988·British Journal of Haematology·C S ScottB E Roberts
Jul 1, 1987·British Journal of Cancer·A N StarkC S Scott
Nov 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·T Balazs, R R Roepke
Jan 1, 1984·Pathology·C CapellaV Eusebi
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·P U Heitz, W Wegmann
Apr 1, 1981·The American Journal of Surgical Pathology·P Isaacson
Nov 1, 1994·The American Journal of Surgical Pathology·S T YuenJ Ho
Jul 1, 1993·The American Journal of Surgical Pathology·S PittalugaS L Loke

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Citations

May 16, 2008·Fish & Shellfish Immunology·Rosa M Jiménez-CantizanoManuel Manchado
Mar 16, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Paulo André Dias BastosRui Miguel Pinheiro Vitorino
Oct 30, 2003·British Journal of Cancer·D ArangoL H Augenlicht
Sep 26, 2019·Protein and Peptide Letters·Mithoor DivyashreeDebmalya Barh

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