PMID: 7544229Aug 1, 1995Paper

Up-regulation of MHC class I by flavivirus-induced peptide translocation into the endoplasmic reticulum

Immunity
A Mullbacher, M Lobigs

Abstract

Flavivirus infection of mammalian cells increases the cell surface expression of major histocompatibility complex (MHC) class I molecules, the recognition elements for cytotoxic T cells. Here, we show that the mechanism for flavivirus-induced up-regulation of class I MHC involves an increase in peptide supply to the endoplasmic reticulum. Flavivirus-mediated peptide supply for MHC class I assembly is independent of the peptide transporters for class I antigen presentation, since infection of class I MHC peptide transport-deficient cell lines with flaviviruses results in the cell surface expression of biologically functional class I MHC peptide complexes. The flavivirus-induced supply of antigenic peptides to the endoplasmic reticulum is not restricted to flavivirus-encoded peptides and independent of interferon. The data imply that peptide availability regulates surface expression of class I MHC restriction elements and suggests a mechanism for flavivirus-induced immunopathology.

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Citations

Feb 1, 1996·Current Opinion in Immunology·P J Lehner, P Cresswell
Aug 1, 1997·Current Opinion in Immunology·H Hengel, U H Koszinowski
Jan 22, 2003·Immunology and Cell Biology·Scott M WardEric J Gowans
Apr 6, 2004·Immunology and Cell Biology·Mario LobigsEva Lee
Jun 3, 1999·Scandinavian Journal of Immunology·A MüllbacherR Langman
May 20, 2003·Immunology and Cell Biology·Michael S Diamond
May 20, 2003·Immunology and Cell Biology·Mario LobigsMatthias Regner
May 20, 2003·Immunology and Cell Biology·Nicholas J C King, Alison M Kesson
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·P GilleceK Römisch
Jun 26, 2002·Viral Immunology·Alison M KessonNicholas J C King
Oct 9, 2002·Journal of Virology·Martin J RafteryGünther Schönrich
Mar 9, 2002·Journal of Virology·Rosa M Licon LunaMario Lobigs
Apr 1, 1997·The Journal of Clinical Investigation·F V Chisari
May 3, 2003·The Journal of Clinical Investigation·Nathan R MartinezLeonard C Harrison
Jul 5, 2013·European Journal of Immunology·Pritesh LalwaniGünther Schönrich
Nov 17, 2012·Vaccine·Jing YeShengbo Cao
Nov 13, 2004·Immunity·Stephen M Hedrick
Apr 22, 2009·Cell Host & Microbe·Maria-Dolores Fernandez-GarciaAli Amara
May 16, 2014·Frontiers in Immunology·Davis Beltrán, Sandra López-Vergès
Jul 6, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Juliane W SchottAxel Schambach
Mar 9, 2012·Expert Review of Anti-infective Therapy·Rami YossefAngel Porgador
Aug 25, 2012·Uirusu·Tomohiro Ishikawa, Eiji Konishi
Jan 18, 2020·Pathogens·Stephanea Sotcheff, Andrew Routh
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saghar KaabinejadianWilliam H Hildebrand
Jun 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abi G AleyasSeong Kug Eo
Nov 7, 2019·Viral Immunology·Branden R NelsonKristina M Adams Waldorf
Jan 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Therese WeiderSara Salehi Hammerstad
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abi G AleyasSeong Kug Eo

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