Abstract
Glioblastoma multiforme (GBM) is the most common and lethal type of primary malignant brain tumor. In recent years, increasing reports suggest that discovery of microRNAs (miRNAs) might provide a novel therapeutical target for human cancers, including GBM. The expression and roles of microRNA-183 (miR-183) has been explored in several types of human cancers, including in GBM, and plays important roles in tumor initiation and progression. However, its biological functions in GBM remain largely unknown. In this study, we demonstrated that miR-183 was significantly up-regulated in astrocytoma tissues and glioblastoma cell lines. Introduction of miR-183 mimics into U251 cells could promoted, while its antisense oligos inhibited cell proliferation and invasion. Moreover, we identified neurofilament light polypeptide (NEFL) as a novel target gene of miR-183. The expression levels of NEFL are inversely correlated with that of miR-183 in human astrocytoma clinical specimens. In addition, NEFL-siRNA could significantly attenuate the inhibitory effects of knockdown miR-183 on the proliferation and invasion of U251 cells via mTOR signaling pathway. Overall, This study revealed that miR-183 promotes glioma cell proliferation by targeting N...Continue Reading
References
Aug 3, 2002·Nature Reviews. Cancer·Yuan Zhu, Luis F Parada
Sep 13, 2002·The Journal of Biological Chemistry·Luciana A HaddadVijaya Ramesh
Jan 28, 2004·Cell·David P Bartel
Jun 16, 2004·International Journal of Cancer. Journal International Du Cancer·Steven W CoonDaniel L Van Dyke
Jun 10, 2005·Nature·Jun LuTodd R Golub
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Jan 17, 2012·Molecular Cancer Research : MCR·Baishen ChenZhongmin Guo
Apr 19, 2012·Lancet·Damien RicardJean-Yves Delattre
Jul 28, 2012·Current Cancer Drug Targets·Hailin TangMinghua Wu
Dec 21, 2012·Current Cancer Drug Targets·Hailin TangGuiyuan Li
Dec 25, 2012·Journal of Neuro-oncology·Hirotomo TanakaEiji Kohmura
Apr 4, 2013·Oncotarget·Hae Kyung LeeChaya Brodie
Sep 13, 2013·International Journal of Oncology·Seongeun KangSun Jung Kim
Jan 10, 2014·PloS One·Hailin TangGuiyuan Li
Aug 26, 2014·Biochemical and Biophysical Research Communications·Mingning QiuHege Chen
Sep 12, 2014·British Journal of Cancer·L-H RenR-H Shi
Nov 15, 2014·Breast Cancer Research : BCR·Pei LiQubo Zhu
Dec 19, 2014·Molecules and Cells·Miao YangYi Wang
Jan 22, 2015·Oncotarget·Zeyou WangMinghua Wu
Feb 20, 2015·Molecular Medicine Reports·Qingquan ZhangHongtao Zhu
Mar 18, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying-Ying LuYue Zeng
Mar 31, 2015·Cancer Letters·Wilson K C LeungNathalie Wong
Apr 2, 2015·Oncotarget·Xiaoping LiuMinghua Wu
May 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liqun ZhangXiaoyu Che
Jun 13, 2015·Oncology Reports·Chuankui WeiLin Fang
Jul 26, 2015·Molecular and Cellular Biochemistry·Gang PengWeixi Jiang
Citations
Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guanghui WangCongying Li
Feb 2, 2018·Journal of Hypertension·Saiful A MirSucheta M Vaingankar
Feb 13, 2018·Journal of Cellular and Molecular Medicine·Yuling DiaoWenke Zhou
Apr 17, 2019·Molecular Pain·Feng-Rui YangQu-Lian Guo
Jul 18, 2017·Oncology Reports·Jinsheng YangJunchao Fang
Nov 16, 2019·Journal of Cellular and Molecular Medicine·Juxian GuHongwei Hu
Feb 15, 2018·Cancer Biomarkers : Section a of Disease Markers·Jinhua YanPing Li
Apr 16, 2016·Oncotarget·Yi MaXiang-Feng Chen
Aug 9, 2016·Oncology Reports·Xiaogang LiuBing Liu
Apr 5, 2018·Oncology Letters·Jia-Min GaoRong-Quan He
May 30, 2019·Technology in Cancer Research & Treatment·Yuan ZhangJie Gong
Sep 21, 2018·Frontiers in Cellular Neuroscience·Xingchun GaoXingchun Gou
Jan 14, 2021·Human Molecular Genetics·Ana M CardosoAmália S Jurado
Apr 4, 2021·Cancers·Swalih P AhmedMehdi H Shahi
Oct 4, 2020·Experimental and Molecular Pathology·Omidvar RezaeiSoudeh Ghafouri-Fard