Up-Regulation of microRNA-183 Promotes Cell Proliferation and Invasion in Glioma By Directly Targeting NEFL

Cellular and Molecular Neurobiology
Zeyou WangMinhui Dai

Abstract

Glioblastoma multiforme (GBM) is the most common and lethal type of primary malignant brain tumor. In recent years, increasing reports suggest that discovery of microRNAs (miRNAs) might provide a novel therapeutical target for human cancers, including GBM. The expression and roles of microRNA-183 (miR-183) has been explored in several types of human cancers, including in GBM, and plays important roles in tumor initiation and progression. However, its biological functions in GBM remain largely unknown. In this study, we demonstrated that miR-183 was significantly up-regulated in astrocytoma tissues and glioblastoma cell lines. Introduction of miR-183 mimics into U251 cells could promoted, while its antisense oligos inhibited cell proliferation and invasion. Moreover, we identified neurofilament light polypeptide (NEFL) as a novel target gene of miR-183. The expression levels of NEFL are inversely correlated with that of miR-183 in human astrocytoma clinical specimens. In addition, NEFL-siRNA could significantly attenuate the inhibitory effects of knockdown miR-183 on the proliferation and invasion of U251 cells via mTOR signaling pathway. Overall, This study revealed that miR-183 promotes glioma cell proliferation by targeting N...Continue Reading

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Citations

Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guanghui WangCongying Li
Feb 13, 2018·Journal of Cellular and Molecular Medicine·Yuling DiaoWenke Zhou
Nov 16, 2019·Journal of Cellular and Molecular Medicine·Juxian GuHongwei Hu
Feb 15, 2018·Cancer Biomarkers : Section a of Disease Markers·Jinhua YanPing Li
May 30, 2019·Technology in Cancer Research & Treatment·Yuan ZhangJie Gong
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Apr 4, 2021·Cancers·Swalih P AhmedMehdi H Shahi
Oct 4, 2020·Experimental and Molecular Pathology·Omidvar RezaeiSoudeh Ghafouri-Fard

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