PMID: 9443927Jan 28, 1998Paper

Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy

Molecular Pharmacology
C SchwarzerG Sperk

Abstract

Receptor autoradiography with the Y2 receptor ligand 125I-peptide YY3-36 and in situ hybridization were applied to investigate changes in neuropeptide tyrosine-Y2 receptor expression after kainic acid-induced recurrent seizures in the rat hippocampus. In the strata oriens and radiatum of CA1 to CA3, which are densely innervated by Y2 receptor-bearing Schaffer collateral terminals, a transient 2-fold increase in Y2 receptor affinity was observed after 4-12 hr, with a later slow decline. No change was seen in Y2 mRNA expression in CA2/CA3 pyramidal cells, from which Schaffer collaterals originate. Conversely, in granule cells of the dentate gyrus, markedly elevated Y2 mRNA concentrations were observed (by 740% in the dorsal hippocampus) 24-48 hr after kainate injection. At the same time, a marked and lasting (up to 6 months) increase in the number of Y2 receptor sites (by 800%) was seen in the dentate hilus, which is innervated densely by mossy fibers. The early increase in Y2 receptor affinity in Schaffer collaterals was accompanied by a 60% decrease in the EC50 of peptide YY3-36 in inhibiting K(+)-stimulated glutamate release in hippocampal slices from kainic acid-treated rats. Our data indicate transient up-regulation of presy...Continue Reading

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Citations

Jul 13, 1999·Journal of Neurophysiology·P R PatryloA Williamson
Mar 3, 2007·The European Journal of Neuroscience·Margaret J MorrisTerence J O'Brien
Sep 11, 2007·British Journal of Pharmacology·S L Parker, A Balasubramaniam
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Meinrad DrexelGünther Sperk
Sep 30, 2005·The European Journal of Neuroscience·Bouchaïb El BahhWilliam F Colmers
Jan 1, 2010·Hippocampus·Marco LedriMerab Kokaia
Nov 28, 2002·Diabetes·Amanda SainsburyHerbert Herzog
Jun 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Amanda SainsburyHerbert Herzog
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tim KarlHerbert Herzog
Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walter WittmannChristoph Schwarzer
Apr 8, 2014·Molecular Neurobiology·Elke ClynenJean-Michel Rigo
Feb 8, 2018·Pharmaceuticals·José J Jarero-BasultoCarlos Beas-Zarate
Jul 23, 1999·Progress in Neurobiology·F Bordi, A Ugolini

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