Up-regulation of p27Kip1 correlates inversely with anchorage-independent growth of human cancer cell lines

Japanese Journal of Cancer Research : Gann
M KawadaT Tsuruo

Abstract

We examined the correlation between anchorage-independent growth and cell cycle-related molecules using 39 human cancer cell lines. They consisted of lung-, colon-, stomach-, breast-, ovarian-, brain-, renal- and melanoma-derived cell lines. Their anchorage-independent growth ability varied, but was not clearly related to the tissue of origin. There was a tendency for the levels of cyclin D1, cyclin E, cyclin A, p27, and p21 to show a tissue-dependent expression pattern. Statistical analysis revealed an inverse correlation of the p27 level with anchorage-independent growth (r=-0.456, P<0.01). Thus, the regulation of p27 is suggested to be linked to the anchorage independence of human cancer cells.

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Citations

Feb 13, 2001·Biochemical and Biophysical Research Communications·Y YamazakiH Koide
Apr 6, 1999·Japanese Journal of Cancer Research : Gann·M KawadaT Takeuchi
Feb 27, 2001·Current Opinion in Oncology·S Halachmi, B A Gilchrest
Mar 29, 2000·Journal of Neurochemistry·T FuseK Yamada
May 15, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Fumiyuki YamasakiKaoru Kurisu
Jan 14, 2021·International Journal of Molecular Sciences·Han Yeoung LeeJong Kook Park

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